Relationship between ciliary blood flow and aqueous production: Does it play a role in glaucoma therapy?

Jeffrey W. Kiel, Herbert A. Reitsamer

Research output: Contribution to journalReview article

12 Scopus citations

Abstract

This review will summarize the authors' recent studies of the relationship between ciliary blood flow and aqueous production, and discuss the relevance of that relationship to the mechanisms of action of glaucoma drugs that lower intraocular pressure by inhibiting aqueous production. The ciliary processes are not easily accessible, and so the data presented necessarily come from animals and from instrumentation operated at its engineering limits. Verification of the findings in humans, and perhaps refinement of the interpretations, must await future advances in technology. Nonetheless, the results to date are intriguing, and may help explain some paradoxes in glaucoma pharmacology.

Original languageEnglish (US)
Pages (from-to)172-181
Number of pages10
JournalJournal of Glaucoma
Volume15
Issue number2
DOIs
StatePublished - Apr 1 2006

Keywords

  • Aqueous dynamics
  • Ciliary body
  • Intraocular pressure
  • Oxygen
  • Rabbit
  • Regional circulation

ASJC Scopus subject areas

  • Ophthalmology

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