Abstract
This review will summarize the authors' recent studies of the relationship between ciliary blood flow and aqueous production, and discuss the relevance of that relationship to the mechanisms of action of glaucoma drugs that lower intraocular pressure by inhibiting aqueous production. The ciliary processes are not easily accessible, and so the data presented necessarily come from animals and from instrumentation operated at its engineering limits. Verification of the findings in humans, and perhaps refinement of the interpretations, must await future advances in technology. Nonetheless, the results to date are intriguing, and may help explain some paradoxes in glaucoma pharmacology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 172-181 |
| Number of pages | 10 |
| Journal | Journal of Glaucoma |
| Volume | 15 |
| Issue number | 2 |
| DOIs | |
| State | Published - Apr 2006 |
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Keywords
- Aqueous dynamics
- Ciliary body
- Intraocular pressure
- Oxygen
- Rabbit
- Regional circulation
ASJC Scopus subject areas
- Ophthalmology
Cite this
Relationship between ciliary blood flow and aqueous production : Does it play a role in glaucoma therapy? / Kiel, Jeffrey W.; Reitsamer, Herbert A.
In: Journal of Glaucoma, Vol. 15, No. 2, 04.2006, p. 172-181.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Relationship between ciliary blood flow and aqueous production
T2 - Does it play a role in glaucoma therapy?
AU - Kiel, Jeffrey W.
AU - Reitsamer, Herbert A.
PY - 2006/4
Y1 - 2006/4
N2 - This review will summarize the authors' recent studies of the relationship between ciliary blood flow and aqueous production, and discuss the relevance of that relationship to the mechanisms of action of glaucoma drugs that lower intraocular pressure by inhibiting aqueous production. The ciliary processes are not easily accessible, and so the data presented necessarily come from animals and from instrumentation operated at its engineering limits. Verification of the findings in humans, and perhaps refinement of the interpretations, must await future advances in technology. Nonetheless, the results to date are intriguing, and may help explain some paradoxes in glaucoma pharmacology.
AB - This review will summarize the authors' recent studies of the relationship between ciliary blood flow and aqueous production, and discuss the relevance of that relationship to the mechanisms of action of glaucoma drugs that lower intraocular pressure by inhibiting aqueous production. The ciliary processes are not easily accessible, and so the data presented necessarily come from animals and from instrumentation operated at its engineering limits. Verification of the findings in humans, and perhaps refinement of the interpretations, must await future advances in technology. Nonetheless, the results to date are intriguing, and may help explain some paradoxes in glaucoma pharmacology.
KW - Aqueous dynamics
KW - Ciliary body
KW - Intraocular pressure
KW - Oxygen
KW - Rabbit
KW - Regional circulation
UR - http://www.scopus.com/inward/record.url?scp=33646771805&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646771805&partnerID=8YFLogxK
U2 - 10.1097/00061198-200604000-00015
DO - 10.1097/00061198-200604000-00015
M3 - Article
C2 - 16633232
AN - SCOPUS:33646771805
VL - 15
SP - 172
EP - 181
JO - Journal of Glaucoma
JF - Journal of Glaucoma
SN - 1057-0829
IS - 2
ER -