Relationship between alveolar saturated phosphatidylcholine pool sizes and compliance of preterm rabbit lungs. The effect of maternal corticosteroid treatment

M. Ikegami, A. H. Jobe, T. Yamada, S. Seidner

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

The relationship between alveolar saturated phosphatidylcholine pool size and compliance was evaluated in control and maternal corticosteroid-treated 27-, 28-, and 29-day gestational age preterm ventilated rabbits. Surfactant pool sizes below about 0.7 μmol saturated phosphatidylcholine/kg body weight did not alter compliance in either group. Compliance increased to values comparable to surfactant-treated or term newborn rabbits over a narrow range of saturated phosphatidylcholine pool sizes from about 0.7 to 1.2 μmol/kg for corticosteroid-treated rabbits and from about 0.9 to about 2.3 μmol/kg for control rabbits (p < 0.01). When these results are compared with those from surfactant-treated rabbits, almost an order of magnitude less endogenous surfactant than exogenous surfactant is needed to alter compliance in preterm ventilated rabbits.

Original languageEnglish (US)
Pages (from-to)367-369
Number of pages3
JournalAmerican Review of Respiratory Disease
Volume139
Issue number2
DOIs
StatePublished - 1989
Externally publishedYes

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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