Relación entre disfunción renal aguda y valores séricos de procalcitonina en pacientes críticos con infección por gripe

Translated title of the contribution: Relationship between acute kidney injury and serum procalcitonin (PCT) concentration in critically ill patients with influenza infection

A. Rodríguez, L. F. Reyes, J. Monclou, B. Suberviola, M. Bodí, G. Sirgo, J. Solé-Violán, J. Guardiola, D. Barahona, E. Díaz, I. Martín-Loeches, Marcos Restrepo

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Introduction: Serum procalcitonin (PCT) concentration could be increased in patients with renal dysfunction in the absence of bacterial infection. Objective: To determine the interactions among serum renal biomarkers of acute kidney injury (AKI) and serum PCT concentration, in patients admitted to the intensive care unit (ICU) due to lung influenza infection. Design: Secondary analysis of a prospective multicentre observational study. Setting: 148 Spanish ICUs. Patients: ICU patients admitted with influenza infection without bacterial co-infection. Clinical, laboratory and hemodynamic variables were recorded. AKI was classified as AKI I or II based on creatinine (Cr) concentrations (≥1.60–2.50 mg/dL and Cr ≥ 2.51–3.99 mg/dL, respectively). Patients with chronic renal disease, receiving renal replacement treatment or with Cr > 4 mg/dL were excluded. Spearman's correlation, simple and multiple linear regression analysis were performed. Interventions: None. Results: Out of 663 patients included in the study, 52 (8.2%) and 10 (1.6%) developed AKI I and II, respectively. Patients with AKI were significantly older, had more comorbid conditions and were more severally ill. PCT concentrations were higher in patients with AKI (2.62 [0.60–10.0] ng/mL vs. 0.40 [0.13–1.20] ng/mL, p = 0.002). Weak correlations between Cr/PCT (rho = 0.18) and Urea (U)/PCT (rho = 0.19) were identified. Simple linear regression showed poor interaction between Cr/U and PCT concentrations (Cr R2 = 0.03 and U R2 = 0.018). Similar results were observed during multiple linear regression analysis (Cr R2 = 0.046 and U R2 = 0.013). Conclusions: Although PCT concentrations were slightly higher in patients with AKI, high PCT concentrations are not explained by AKI and could be warning sign of a potential bacterial infection.

Original languageSpanish
JournalMedicina Intensiva
DOIs
StateAccepted/In press - Jan 1 2018

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Calcitonin
Acute Kidney Injury
Critical Illness
Human Influenza
Creatinine
Infection
Serum
Bacterial Infections
Linear Models
Kidney
Intensive Care Units
Regression Analysis
Coinfection
Chronic Renal Insufficiency
Multicenter Studies
Observational Studies
Urea
Patient Care
Biomarkers
Hemodynamics

Keywords

  • Creatinine
  • Influenza
  • Procalcitonin
  • Renal dysfunction
  • Urea

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

Cite this

Relación entre disfunción renal aguda y valores séricos de procalcitonina en pacientes críticos con infección por gripe. / Rodríguez, A.; Reyes, L. F.; Monclou, J.; Suberviola, B.; Bodí, M.; Sirgo, G.; Solé-Violán, J.; Guardiola, J.; Barahona, D.; Díaz, E.; Martín-Loeches, I.; Restrepo, Marcos.

In: Medicina Intensiva, 01.01.2018.

Research output: Contribution to journalArticle

Rodríguez, A, Reyes, LF, Monclou, J, Suberviola, B, Bodí, M, Sirgo, G, Solé-Violán, J, Guardiola, J, Barahona, D, Díaz, E, Martín-Loeches, I & Restrepo, M 2018, 'Relación entre disfunción renal aguda y valores séricos de procalcitonina en pacientes críticos con infección por gripe', Medicina Intensiva. https://doi.org/10.1016/j.medin.2017.12.004
Rodríguez, A. ; Reyes, L. F. ; Monclou, J. ; Suberviola, B. ; Bodí, M. ; Sirgo, G. ; Solé-Violán, J. ; Guardiola, J. ; Barahona, D. ; Díaz, E. ; Martín-Loeches, I. ; Restrepo, Marcos. / Relación entre disfunción renal aguda y valores séricos de procalcitonina en pacientes críticos con infección por gripe. In: Medicina Intensiva. 2018.
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abstract = "Introduction: Serum procalcitonin (PCT) concentration could be increased in patients with renal dysfunction in the absence of bacterial infection. Objective: To determine the interactions among serum renal biomarkers of acute kidney injury (AKI) and serum PCT concentration, in patients admitted to the intensive care unit (ICU) due to lung influenza infection. Design: Secondary analysis of a prospective multicentre observational study. Setting: 148 Spanish ICUs. Patients: ICU patients admitted with influenza infection without bacterial co-infection. Clinical, laboratory and hemodynamic variables were recorded. AKI was classified as AKI I or II based on creatinine (Cr) concentrations (≥1.60–2.50 mg/dL and Cr ≥ 2.51–3.99 mg/dL, respectively). Patients with chronic renal disease, receiving renal replacement treatment or with Cr > 4 mg/dL were excluded. Spearman's correlation, simple and multiple linear regression analysis were performed. Interventions: None. Results: Out of 663 patients included in the study, 52 (8.2{\%}) and 10 (1.6{\%}) developed AKI I and II, respectively. Patients with AKI were significantly older, had more comorbid conditions and were more severally ill. PCT concentrations were higher in patients with AKI (2.62 [0.60–10.0] ng/mL vs. 0.40 [0.13–1.20] ng/mL, p = 0.002). Weak correlations between Cr/PCT (rho = 0.18) and Urea (U)/PCT (rho = 0.19) were identified. Simple linear regression showed poor interaction between Cr/U and PCT concentrations (Cr R2 = 0.03 and U R2 = 0.018). Similar results were observed during multiple linear regression analysis (Cr R2 = 0.046 and U R2 = 0.013). Conclusions: Although PCT concentrations were slightly higher in patients with AKI, high PCT concentrations are not explained by AKI and could be warning sign of a potential bacterial infection.",
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T1 - Relación entre disfunción renal aguda y valores séricos de procalcitonina en pacientes críticos con infección por gripe

AU - Rodríguez, A.

AU - Reyes, L. F.

AU - Monclou, J.

AU - Suberviola, B.

AU - Bodí, M.

AU - Sirgo, G.

AU - Solé-Violán, J.

AU - Guardiola, J.

AU - Barahona, D.

AU - Díaz, E.

AU - Martín-Loeches, I.

AU - Restrepo, Marcos

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Introduction: Serum procalcitonin (PCT) concentration could be increased in patients with renal dysfunction in the absence of bacterial infection. Objective: To determine the interactions among serum renal biomarkers of acute kidney injury (AKI) and serum PCT concentration, in patients admitted to the intensive care unit (ICU) due to lung influenza infection. Design: Secondary analysis of a prospective multicentre observational study. Setting: 148 Spanish ICUs. Patients: ICU patients admitted with influenza infection without bacterial co-infection. Clinical, laboratory and hemodynamic variables were recorded. AKI was classified as AKI I or II based on creatinine (Cr) concentrations (≥1.60–2.50 mg/dL and Cr ≥ 2.51–3.99 mg/dL, respectively). Patients with chronic renal disease, receiving renal replacement treatment or with Cr > 4 mg/dL were excluded. Spearman's correlation, simple and multiple linear regression analysis were performed. Interventions: None. Results: Out of 663 patients included in the study, 52 (8.2%) and 10 (1.6%) developed AKI I and II, respectively. Patients with AKI were significantly older, had more comorbid conditions and were more severally ill. PCT concentrations were higher in patients with AKI (2.62 [0.60–10.0] ng/mL vs. 0.40 [0.13–1.20] ng/mL, p = 0.002). Weak correlations between Cr/PCT (rho = 0.18) and Urea (U)/PCT (rho = 0.19) were identified. Simple linear regression showed poor interaction between Cr/U and PCT concentrations (Cr R2 = 0.03 and U R2 = 0.018). Similar results were observed during multiple linear regression analysis (Cr R2 = 0.046 and U R2 = 0.013). Conclusions: Although PCT concentrations were slightly higher in patients with AKI, high PCT concentrations are not explained by AKI and could be warning sign of a potential bacterial infection.

AB - Introduction: Serum procalcitonin (PCT) concentration could be increased in patients with renal dysfunction in the absence of bacterial infection. Objective: To determine the interactions among serum renal biomarkers of acute kidney injury (AKI) and serum PCT concentration, in patients admitted to the intensive care unit (ICU) due to lung influenza infection. Design: Secondary analysis of a prospective multicentre observational study. Setting: 148 Spanish ICUs. Patients: ICU patients admitted with influenza infection without bacterial co-infection. Clinical, laboratory and hemodynamic variables were recorded. AKI was classified as AKI I or II based on creatinine (Cr) concentrations (≥1.60–2.50 mg/dL and Cr ≥ 2.51–3.99 mg/dL, respectively). Patients with chronic renal disease, receiving renal replacement treatment or with Cr > 4 mg/dL were excluded. Spearman's correlation, simple and multiple linear regression analysis were performed. Interventions: None. Results: Out of 663 patients included in the study, 52 (8.2%) and 10 (1.6%) developed AKI I and II, respectively. Patients with AKI were significantly older, had more comorbid conditions and were more severally ill. PCT concentrations were higher in patients with AKI (2.62 [0.60–10.0] ng/mL vs. 0.40 [0.13–1.20] ng/mL, p = 0.002). Weak correlations between Cr/PCT (rho = 0.18) and Urea (U)/PCT (rho = 0.19) were identified. Simple linear regression showed poor interaction between Cr/U and PCT concentrations (Cr R2 = 0.03 and U R2 = 0.018). Similar results were observed during multiple linear regression analysis (Cr R2 = 0.046 and U R2 = 0.013). Conclusions: Although PCT concentrations were slightly higher in patients with AKI, high PCT concentrations are not explained by AKI and could be warning sign of a potential bacterial infection.

KW - Creatinine

KW - Influenza

KW - Procalcitonin

KW - Renal dysfunction

KW - Urea

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