TY - JOUR
T1 - Relations of plasma homocysteine to left ventricular structure and function
T2 - The Framingham Heart Study
AU - Sundström, Johan
AU - Sullivan, Lisa
AU - Selhub, Jacob
AU - Benjamin, Emelia J.
AU - D'Agostino, Ralph B.
AU - Jacques, Paul F.
AU - Rosenberg, Irwin H.
AU - Levy, Daniel
AU - Wilson, Peter W.F.
AU - Vasan, Ramachandran S.
PY - 2004/3
Y1 - 2004/3
N2 - Aims: Hyperhomocysteinaemia is a risk factor for congestive heart failure, especially in women. We investigated if homocysteine promotes left ventricular (LV) remodelling. Methods and results: We examined cross-sectional relations of plasma total homocysteine to echocardiographic LV structure and function in 2697 Framingham Heart Study participants (mean age 58 years, 58% women) free of heart failure and previous myocardial infarction. Adjusting for age and height, plasma homocysteine was positively related to LV mass, watt thickness, and relative watt thickness in women (p = 0.0004-0.04), but not in men (p = 0.28-0.68). Adjusting additionally for other clinical covariates, the relations of plasma homocysteine to LV mass and wall thickness in women remained statistically significant, but the relation to relative watt thickness became of borderline significance (1.92 g, 0.01 cm, and 0.29% increase, respectively, for a 1-SD increase in ln[homocysteine], p = 0.01-0.08). LV mass and wall thickness were higher in the fourth quartile of plasma homocysteine compared to the lower three in all models in women (p = 0.0003-0.02), but not in men (p = 0.25-0.78). Plasma homocysteine was not related to left atrial size or LV fractional shortening in either sex. Conclusion: In our community-based sample, plasma homocysteine was directly related to LV mass and wall thickness in women but not in men.
AB - Aims: Hyperhomocysteinaemia is a risk factor for congestive heart failure, especially in women. We investigated if homocysteine promotes left ventricular (LV) remodelling. Methods and results: We examined cross-sectional relations of plasma total homocysteine to echocardiographic LV structure and function in 2697 Framingham Heart Study participants (mean age 58 years, 58% women) free of heart failure and previous myocardial infarction. Adjusting for age and height, plasma homocysteine was positively related to LV mass, watt thickness, and relative watt thickness in women (p = 0.0004-0.04), but not in men (p = 0.28-0.68). Adjusting additionally for other clinical covariates, the relations of plasma homocysteine to LV mass and wall thickness in women remained statistically significant, but the relation to relative watt thickness became of borderline significance (1.92 g, 0.01 cm, and 0.29% increase, respectively, for a 1-SD increase in ln[homocysteine], p = 0.01-0.08). LV mass and wall thickness were higher in the fourth quartile of plasma homocysteine compared to the lower three in all models in women (p = 0.0003-0.02), but not in men (p = 0.25-0.78). Plasma homocysteine was not related to left atrial size or LV fractional shortening in either sex. Conclusion: In our community-based sample, plasma homocysteine was directly related to LV mass and wall thickness in women but not in men.
KW - Echocardiography
KW - Heart failure
KW - Left Ventricular hypertrophy
KW - Left ventricular remodelling
KW - Metabolism
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U2 - 10.1016/j.ehj.2004.01.008
DO - 10.1016/j.ehj.2004.01.008
M3 - Article
C2 - 15039133
AN - SCOPUS:11144356292
SN - 0195-668X
VL - 25
SP - 523
EP - 530
JO - European Heart Journal
JF - European Heart Journal
IS - 6
ER -