Relations of mitochondrial genetic variants to measures of vascular function

Jessica L. Fetterman, Chunyu Liu, Gary F. Mitchell, Ramachandran S. Vasan, Emelia J. Benjamin, Joseph A. Vita, Naomi M. Hamburg, Daniel Levy

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Mitochondrial genetic variation with resultant alterations in oxidative phosphorylation may influence vascular function and contribute to cardiovascular disease susceptibility. We assessed relations of peptide-encoding variants in the mitochondrial genome with measures of vascular function in Framingham Heart Study participants. Of 258 variants assessed, 40 were predicted to have functional consequences by bioinformatics programs. A maternal pattern of heritability was estimated to contribute to the variability of aortic stiffness. A putative association with a microvascular function measure was identified that requires replication. The methods we have developed can be applied to assess the relations of mitochondrial genetic variation to other phenotypes.

Original languageEnglish (US)
Pages (from-to)51-57
Number of pages7
JournalMitochondrion
Volume40
DOIs
StatePublished - May 2018
Externally publishedYes

Keywords

  • Mitochondrial genetics
  • Vascular function

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

Fingerprint

Dive into the research topics of 'Relations of mitochondrial genetic variants to measures of vascular function'. Together they form a unique fingerprint.

Cite this