Relations between plasma microRNAs, echocardiographic markers of atrial remodeling, and atrial fibrillation: Data from the Framingham Offspring study

Aditya Vaze, Khanh Van Tran, Kahraman Tanriverdi, Mayank Sardana, Darleen Lessard, J. Kevin Donahue, Bruce Barton, Gerard Aurigemma, Steven A. Lubitz, Honghuang Lin, George H. Nasr, Amiya Mandapati, Emelia J. Benjamin, Ramachandran S. Vasan, Jane E. Freedman, David D. McManus

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Background Circulating microRNAs may reflect or influence pathological cardiac remodeling and contribute to atrial fibrillation (AF). Objective The purpose of this study was to identify candidate plasma microRNAs that are associated with echocardiographic phenotypes of atrial remodeling, and incident and prevalent AF in a community-based cohort. Methods We analyzed left atrial function index (LAFI) of 1788 Framingham Offspring 8 participants. We quantified expression of 339 plasma microRNAs. We examined associations between microRNA levels with LAFI and prevalent and incident AF. We constructed pathway analysis of microRNAs’ predicted gene targets to identify molecular processes involved in adverse atrial remodeling in AF. Results The mean age of the participants was 66 ± 9 years, and 54% were women. Five percent of participants had prevalent AF at the initial examination and 9% (n = 157) developed AF over a median 8.6 years of follow-up (IQR 8.1–9.2 years). Plasma microRNAs were associated with LAFI (N = 73, p<0.0001). Six of these plasma microRNAs were significantly associated with incident AF, including 4 also associated with prevalent AF (microRNAs 106b, 26a-5p, 484, 20a-5p). These microRNAs are predicted to regulate genes involved in cardiac hypertrophy, inflammation, and myocardial fibrosis. Conclusions Circulating microRNAs 106b, 26a-5p, 484, 20a-5p are associated with atrial remodeling and AF.

Original languageEnglish (US)
Article numbere0236960
JournalPloS one
Volume15
Issue number8 August
DOIs
StatePublished - Aug 2020
Externally publishedYes

ASJC Scopus subject areas

  • General

Fingerprint

Dive into the research topics of 'Relations between plasma microRNAs, echocardiographic markers of atrial remodeling, and atrial fibrillation: Data from the Framingham Offspring study'. Together they form a unique fingerprint.

Cite this