TY - JOUR
T1 - Relation of MRI visible perivascular spaces with global and regional brain structural connectivity measures
T2 - The Framingham Heart Study (FHS)
AU - Ekenze, Oluchi
AU - Seiler, Stephan
AU - Pinheiro, Adlin
AU - DeCarli, Charles
AU - Parva, Pedram
AU - Habes, Mohamad
AU - Charidimou, Andreas
AU - Maillard, Pauline
AU - Beiser, Alexa
AU - Seshadri, Sudha
AU - Demissie, Serkalem
AU - Romero, Jose Rafael
N1 - Publisher Copyright:
© 2025 Elsevier Inc.
PY - 2025/6
Y1 - 2025/6
N2 - MRI visible perivascular spaces (PVS) are associated with cognitive impairment and dementia, which are also associated with disrupted network connectivity. PVS may relate to dementia risk through disruption in brain connectivity. We studied the relation between PVS grade and global and regional structural connectivity in Framingham Heart Study participants free of stroke and dementia. PVS were rated on axial T2 sequences in the basal ganglia (BG) and centrum semiovale (CSO). We assessed structural global and regional network architecture using global efficiency, local efficiency and modularity. Analysis of covariance was used to relate PVS grades with structural network measures. Models adjusted for age, sex (model 1), and vascular risk factors (model 2). Effect modification on the associations by age, sex, hypertension and APOE-ɛ4 status was assessed. Among 2525 participants (mean age 54 ± 13 years, 53 % female), significant associations were observed between grade III and IV PVS in the BG and CSO with reduced global efficiency. Grade III (β −0.0030; 95 % confidence interval [CI] −0.0041, −0.0019) and IV (β −0.0033, CI −0.0060, −0.0007) PVS in the BG and grade IV (β −0.0015; CI −0.0024, −0.0007) PVS in the CSO were associated with reduced local efficiency. We observed shared and different strength of association by age, hypertension, sex and APOE-ɛ4 in the relationship between high burden PVS in the BG and CSO with structural network measures. Findings suggest that higher grade PVS are associated with disruption of global and regional structural brain networks.
AB - MRI visible perivascular spaces (PVS) are associated with cognitive impairment and dementia, which are also associated with disrupted network connectivity. PVS may relate to dementia risk through disruption in brain connectivity. We studied the relation between PVS grade and global and regional structural connectivity in Framingham Heart Study participants free of stroke and dementia. PVS were rated on axial T2 sequences in the basal ganglia (BG) and centrum semiovale (CSO). We assessed structural global and regional network architecture using global efficiency, local efficiency and modularity. Analysis of covariance was used to relate PVS grades with structural network measures. Models adjusted for age, sex (model 1), and vascular risk factors (model 2). Effect modification on the associations by age, sex, hypertension and APOE-ɛ4 status was assessed. Among 2525 participants (mean age 54 ± 13 years, 53 % female), significant associations were observed between grade III and IV PVS in the BG and CSO with reduced global efficiency. Grade III (β −0.0030; 95 % confidence interval [CI] −0.0041, −0.0019) and IV (β −0.0033, CI −0.0060, −0.0007) PVS in the BG and grade IV (β −0.0015; CI −0.0024, −0.0007) PVS in the CSO were associated with reduced local efficiency. We observed shared and different strength of association by age, hypertension, sex and APOE-ɛ4 in the relationship between high burden PVS in the BG and CSO with structural network measures. Findings suggest that higher grade PVS are associated with disruption of global and regional structural brain networks.
KW - Basal ganglia
KW - Centrum semiovale
KW - Global efficiency
KW - Local efficiency
KW - MRI visible perivascular spaces
KW - Modularity
KW - Structural brain connectivity
UR - https://www.scopus.com/pages/publications/85219436718
UR - https://www.scopus.com/inward/citedby.url?scp=85219436718&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2025.02.007
DO - 10.1016/j.neurobiolaging.2025.02.007
M3 - Article
C2 - 40043467
AN - SCOPUS:85219436718
SN - 0197-4580
VL - 150
SP - 1
EP - 8
JO - Neurobiology of Aging
JF - Neurobiology of Aging
ER -