Relation of direct and surrogate measures of insulin resistance to cardiovascular risk factors in nondiabetic Finnish offspring of type 2 diabetic individuals

Carlos Lorenzo, Steven M. Haffner, Alena Stančáková, Markku Laakso

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Context: Methods to directly measure insulin resistance are invasive, complex, and costly. Surrogate indexes derived from the oral glucose tolerance test (OGTT) have been developed, but few studies have systematically analyzed these indexes. Objective: We examined the relation of surrogate and direct measures of insulin resistance to metabolic variables. Design and Setting: We conducted a cross-sectional analysis of the validation cohort of the Metabolic Syndrome in Men study. Participants: Participants included 272 nondiabetic Finnish offspring of type 2 diabetic individuals (age, 24-50 yr; 55% female). Intervention: Surrogate indexes of insulin resistance were computed according to published formulas. Insulin sensitivity was also directly measured by the euglycemic-hyperinsulinemic clamp. Results: The strength of the correlation of the Matsuda index with directly measured insulin sensitivity (r = 0.77) was similar to that of Avignon's insulin sensitivity index (r = 0.76; P = 0.581) and simple index assessing insulin sensitivity using OGTT measurements (r = 0.74; P = 0.060) and stronger than that of indexes derived from fasting measurements [e.g. fasting insulin (r = 0.72; P = 0.011) and homeostasis model assessment of insulin resistance (r = 0.71; P = 0.001)]. Surrogate indexes were similar to directly measured insulin sensitivity in their relationships with metabolic abnormalities including definitive measures of fat distribution. Some indexes, however, had distinctive correlations: McAuley index with lipoproteins and Avignon insulin sensitivity and Stumvoll indexes with adiposity and fibrinogen. Conclusions: Surrogate indexes are valid measures of insulin resistance. Multiple sampling times during an OGTT may not be mandatory to adequately estimate insulin resistance in clinical and epidemiological studies.

Original languageEnglish (US)
Pages (from-to)5082-5090
Number of pages9
JournalJournal of Clinical Endocrinology and Metabolism
Volume95
Issue number11
DOIs
StatePublished - Nov 2010

Fingerprint

Insulin Resistance
Insulin
Glucose Tolerance Test
Glucose
Fasting
Glucose Clamp Technique
Adiposity
Clamping devices
Fibrinogen
Lipoproteins
Epidemiologic Studies
Homeostasis
Cross-Sectional Studies
Fats
Sampling

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Endocrinology
  • Biochemistry, medical
  • Endocrinology, Diabetes and Metabolism

Cite this

Relation of direct and surrogate measures of insulin resistance to cardiovascular risk factors in nondiabetic Finnish offspring of type 2 diabetic individuals. / Lorenzo, Carlos; Haffner, Steven M.; Stančáková, Alena; Laakso, Markku.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 95, No. 11, 11.2010, p. 5082-5090.

Research output: Contribution to journalArticle

@article{951410bb4c3d439b9aca2fd441e1b251,
title = "Relation of direct and surrogate measures of insulin resistance to cardiovascular risk factors in nondiabetic Finnish offspring of type 2 diabetic individuals",
abstract = "Context: Methods to directly measure insulin resistance are invasive, complex, and costly. Surrogate indexes derived from the oral glucose tolerance test (OGTT) have been developed, but few studies have systematically analyzed these indexes. Objective: We examined the relation of surrogate and direct measures of insulin resistance to metabolic variables. Design and Setting: We conducted a cross-sectional analysis of the validation cohort of the Metabolic Syndrome in Men study. Participants: Participants included 272 nondiabetic Finnish offspring of type 2 diabetic individuals (age, 24-50 yr; 55{\%} female). Intervention: Surrogate indexes of insulin resistance were computed according to published formulas. Insulin sensitivity was also directly measured by the euglycemic-hyperinsulinemic clamp. Results: The strength of the correlation of the Matsuda index with directly measured insulin sensitivity (r = 0.77) was similar to that of Avignon's insulin sensitivity index (r = 0.76; P = 0.581) and simple index assessing insulin sensitivity using OGTT measurements (r = 0.74; P = 0.060) and stronger than that of indexes derived from fasting measurements [e.g. fasting insulin (r = 0.72; P = 0.011) and homeostasis model assessment of insulin resistance (r = 0.71; P = 0.001)]. Surrogate indexes were similar to directly measured insulin sensitivity in their relationships with metabolic abnormalities including definitive measures of fat distribution. Some indexes, however, had distinctive correlations: McAuley index with lipoproteins and Avignon insulin sensitivity and Stumvoll indexes with adiposity and fibrinogen. Conclusions: Surrogate indexes are valid measures of insulin resistance. Multiple sampling times during an OGTT may not be mandatory to adequately estimate insulin resistance in clinical and epidemiological studies.",
author = "Carlos Lorenzo and Haffner, {Steven M.} and Alena Stanč{\'a}kov{\'a} and Markku Laakso",
year = "2010",
month = "11",
doi = "10.1210/jc.2010-1144",
language = "English (US)",
volume = "95",
pages = "5082--5090",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "11",

}

TY - JOUR

T1 - Relation of direct and surrogate measures of insulin resistance to cardiovascular risk factors in nondiabetic Finnish offspring of type 2 diabetic individuals

AU - Lorenzo, Carlos

AU - Haffner, Steven M.

AU - Stančáková, Alena

AU - Laakso, Markku

PY - 2010/11

Y1 - 2010/11

N2 - Context: Methods to directly measure insulin resistance are invasive, complex, and costly. Surrogate indexes derived from the oral glucose tolerance test (OGTT) have been developed, but few studies have systematically analyzed these indexes. Objective: We examined the relation of surrogate and direct measures of insulin resistance to metabolic variables. Design and Setting: We conducted a cross-sectional analysis of the validation cohort of the Metabolic Syndrome in Men study. Participants: Participants included 272 nondiabetic Finnish offspring of type 2 diabetic individuals (age, 24-50 yr; 55% female). Intervention: Surrogate indexes of insulin resistance were computed according to published formulas. Insulin sensitivity was also directly measured by the euglycemic-hyperinsulinemic clamp. Results: The strength of the correlation of the Matsuda index with directly measured insulin sensitivity (r = 0.77) was similar to that of Avignon's insulin sensitivity index (r = 0.76; P = 0.581) and simple index assessing insulin sensitivity using OGTT measurements (r = 0.74; P = 0.060) and stronger than that of indexes derived from fasting measurements [e.g. fasting insulin (r = 0.72; P = 0.011) and homeostasis model assessment of insulin resistance (r = 0.71; P = 0.001)]. Surrogate indexes were similar to directly measured insulin sensitivity in their relationships with metabolic abnormalities including definitive measures of fat distribution. Some indexes, however, had distinctive correlations: McAuley index with lipoproteins and Avignon insulin sensitivity and Stumvoll indexes with adiposity and fibrinogen. Conclusions: Surrogate indexes are valid measures of insulin resistance. Multiple sampling times during an OGTT may not be mandatory to adequately estimate insulin resistance in clinical and epidemiological studies.

AB - Context: Methods to directly measure insulin resistance are invasive, complex, and costly. Surrogate indexes derived from the oral glucose tolerance test (OGTT) have been developed, but few studies have systematically analyzed these indexes. Objective: We examined the relation of surrogate and direct measures of insulin resistance to metabolic variables. Design and Setting: We conducted a cross-sectional analysis of the validation cohort of the Metabolic Syndrome in Men study. Participants: Participants included 272 nondiabetic Finnish offspring of type 2 diabetic individuals (age, 24-50 yr; 55% female). Intervention: Surrogate indexes of insulin resistance were computed according to published formulas. Insulin sensitivity was also directly measured by the euglycemic-hyperinsulinemic clamp. Results: The strength of the correlation of the Matsuda index with directly measured insulin sensitivity (r = 0.77) was similar to that of Avignon's insulin sensitivity index (r = 0.76; P = 0.581) and simple index assessing insulin sensitivity using OGTT measurements (r = 0.74; P = 0.060) and stronger than that of indexes derived from fasting measurements [e.g. fasting insulin (r = 0.72; P = 0.011) and homeostasis model assessment of insulin resistance (r = 0.71; P = 0.001)]. Surrogate indexes were similar to directly measured insulin sensitivity in their relationships with metabolic abnormalities including definitive measures of fat distribution. Some indexes, however, had distinctive correlations: McAuley index with lipoproteins and Avignon insulin sensitivity and Stumvoll indexes with adiposity and fibrinogen. Conclusions: Surrogate indexes are valid measures of insulin resistance. Multiple sampling times during an OGTT may not be mandatory to adequately estimate insulin resistance in clinical and epidemiological studies.

UR - http://www.scopus.com/inward/record.url?scp=78049519084&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78049519084&partnerID=8YFLogxK

U2 - 10.1210/jc.2010-1144

DO - 10.1210/jc.2010-1144

M3 - Article

C2 - 20702522

AN - SCOPUS:78049519084

VL - 95

SP - 5082

EP - 5090

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 11

ER -