Abstract
A preclinical model that includes measures of alternative behavior and drug-seeking could improve our understanding of the processes involved in successful recovery; however current preclinical models of relapse do not measure alternative behavior. We assessed the persistence of food-maintained responding and the resumption of ethanol-maintained responding after ethanol-maintained responding was reduced by changing the response requirement for concurrently available food. Ethanol (10%, w/v) was always available following 5 responses (FR5). A 16. kHz tone indicating food delivery followed 150 responses (FR150) resulted in ethanol-predominate responding and substantial amounts of ethanol were earned (0.47. g/kg per 30-min session) and consumed. An 8. kHz tone indicating food delivery followed 5 responses (FR5) for 1, 2, 4, or 16 consecutive sessions reduced ethanol-maintained responding despite unchanged ethanol availability. Ethanol-maintained responding resumed upon subsequent presentation of the 16. kHz tone. However, more responses occurred on the food lever before 5 responses occurred on the ethanol lever as the number of preceding FR5 food sessions increased. These results suggest that alternative reinforcement may reduce control by discriminative stimuli that occasion ethanol-seeking and is consistent with the risk of relapse declining with longer periods of recovery because of the strengthening of alternative behavior.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 60-66 |
| Number of pages | 7 |
| Journal | Behavioural Processes |
| Volume | 94 |
| DOIs | |
| State | Published - Mar 2013 |
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Keywords
- Addiction
- Alcohol
- Operant
- Rat
- Relapse
- Resurgence
- Self-administration
ASJC Scopus subject areas
- Animal Science and Zoology
- Behavioral Neuroscience
Cite this
Reinforcement of an alternative behavior as a model of recovery and relapse in the rat. / Ginsburg, Brett C; Lamb, Richard J.
In: Behavioural Processes, Vol. 94, 03.2013, p. 60-66.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reinforcement of an alternative behavior as a model of recovery and relapse in the rat
AU - Ginsburg, Brett C
AU - Lamb, Richard J
PY - 2013/3
Y1 - 2013/3
N2 - A preclinical model that includes measures of alternative behavior and drug-seeking could improve our understanding of the processes involved in successful recovery; however current preclinical models of relapse do not measure alternative behavior. We assessed the persistence of food-maintained responding and the resumption of ethanol-maintained responding after ethanol-maintained responding was reduced by changing the response requirement for concurrently available food. Ethanol (10%, w/v) was always available following 5 responses (FR5). A 16. kHz tone indicating food delivery followed 150 responses (FR150) resulted in ethanol-predominate responding and substantial amounts of ethanol were earned (0.47. g/kg per 30-min session) and consumed. An 8. kHz tone indicating food delivery followed 5 responses (FR5) for 1, 2, 4, or 16 consecutive sessions reduced ethanol-maintained responding despite unchanged ethanol availability. Ethanol-maintained responding resumed upon subsequent presentation of the 16. kHz tone. However, more responses occurred on the food lever before 5 responses occurred on the ethanol lever as the number of preceding FR5 food sessions increased. These results suggest that alternative reinforcement may reduce control by discriminative stimuli that occasion ethanol-seeking and is consistent with the risk of relapse declining with longer periods of recovery because of the strengthening of alternative behavior.
AB - A preclinical model that includes measures of alternative behavior and drug-seeking could improve our understanding of the processes involved in successful recovery; however current preclinical models of relapse do not measure alternative behavior. We assessed the persistence of food-maintained responding and the resumption of ethanol-maintained responding after ethanol-maintained responding was reduced by changing the response requirement for concurrently available food. Ethanol (10%, w/v) was always available following 5 responses (FR5). A 16. kHz tone indicating food delivery followed 150 responses (FR150) resulted in ethanol-predominate responding and substantial amounts of ethanol were earned (0.47. g/kg per 30-min session) and consumed. An 8. kHz tone indicating food delivery followed 5 responses (FR5) for 1, 2, 4, or 16 consecutive sessions reduced ethanol-maintained responding despite unchanged ethanol availability. Ethanol-maintained responding resumed upon subsequent presentation of the 16. kHz tone. However, more responses occurred on the food lever before 5 responses occurred on the ethanol lever as the number of preceding FR5 food sessions increased. These results suggest that alternative reinforcement may reduce control by discriminative stimuli that occasion ethanol-seeking and is consistent with the risk of relapse declining with longer periods of recovery because of the strengthening of alternative behavior.
KW - Addiction
KW - Alcohol
KW - Operant
KW - Rat
KW - Relapse
KW - Resurgence
KW - Self-administration
UR - http://www.scopus.com/inward/record.url?scp=84875369643&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84875369643&partnerID=8YFLogxK
U2 - 10.1016/j.beproc.2012.12.004
DO - 10.1016/j.beproc.2012.12.004
M3 - Article
C2 - 23274846
AN - SCOPUS:84875369643
VL - 94
SP - 60
EP - 66
JO - Behavioural Processes
JF - Behavioural Processes
SN - 0376-6357
ER -