Regulatory roles of phosphorylation in model and pathogenic fungi

Mohammad T. Albataineh, David Kadosh

Research output: Contribution to journalReview article

9 Scopus citations

Abstract

Over the past 20 years, considerable advances have been made toward our understanding of how post-translational modifications affect a wide variety of biological processes, including morphology and virulence, in medically important fungi. Phosphorylation stands out as a key molecular switch and regulatory modification that plays a critical role in controlling these processes. In this article, we first provide a comprehensive and up-to-date overview of the regulatory roles that both Ser/Thr and non-Ser/Thr kinases and phosphatases play in model and pathogenic fungi. Next, we discuss the impact of current global approaches that are being used to define the complete set of phosphorylation targets (phosphoproteome) in medically important fungi. Finally, we provide new insights and perspectives into the potential use of key regulatory kinases and phosphatases as targets for the development of novel and more effective antifungal strategies.

Original languageEnglish (US)
Pages (from-to)333-352
Number of pages20
JournalMedical Mycology
Volume54
Issue number4
DOIs
StatePublished - Apr 1 2016

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Keywords

  • human fungal pathogens
  • kinases
  • phosphatases
  • phosphoproteome
  • phosphorylation

ASJC Scopus subject areas

  • veterinary(all)
  • Infectious Diseases

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