Regulatory mechanisms of osteoclast differentiation and function

Gregory R. Mundy

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Our understanding of the molecular mechanisms responsible for osteoclast generation, differentiation, and bone resorption have improved dramatically in recent years. In part, this has been due to studies in osteopetrosis, the disease characterized by impairment of osteoclast action, and to improved techniques for isolation of osteoclasts and their precursors. This review will discuss some of these mechanisms.

Original languageEnglish (US)
Pages (from-to)59-64
Number of pages6
JournalJournal of Bone and Mineral Metabolism
Issue number2
StatePublished - 1996
Externally publishedYes


  • Apoptosis
  • Cadherin
  • Osteoclast
  • Osteopetrosis
  • Src

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology


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