Regulatory mechanisms of osteoclast differentiation and function

Gregory R. Mundy

doi:10.1007/BF01768833

Regulatory mechanisms of osteoclast differentiation and function

Gregory R. Mundy

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Our understanding of the molecular mechanisms responsible for osteoclast generation, differentiation, and bone resorption have improved dramatically in recent years. In part, this has been due to studies in osteopetrosis, the disease characterized by impairment of osteoclast action, and to improved techniques for isolation of osteoclasts and their precursors. This review will discuss some of these mechanisms.

Original language	English (US)
Pages (from-to)	59-64
Number of pages	6
Journal	Journal of Bone and Mineral Metabolism
Volume	14
Issue number	2
DOIs	https://doi.org/10.1007/BF01768833
State	Published - 1996
Externally published	Yes

Keywords

Apoptosis
Cadherin
Osteoclast
Osteopetrosis
Src

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Orthopedics and Sports Medicine
Endocrinology

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10.1007/BF01768833

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title = "Regulatory mechanisms of osteoclast differentiation and function",

abstract = "Our understanding of the molecular mechanisms responsible for osteoclast generation, differentiation, and bone resorption have improved dramatically in recent years. In part, this has been due to studies in osteopetrosis, the disease characterized by impairment of osteoclast action, and to improved techniques for isolation of osteoclasts and their precursors. This review will discuss some of these mechanisms.",

keywords = "Apoptosis, Cadherin, Osteoclast, Osteopetrosis, Src",

author = "Mundy, {Gregory R.}",

year = "1996",

doi = "10.1007/BF01768833",

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AU - Mundy, Gregory R.

PY - 1996

Y1 - 1996

N2 - Our understanding of the molecular mechanisms responsible for osteoclast generation, differentiation, and bone resorption have improved dramatically in recent years. In part, this has been due to studies in osteopetrosis, the disease characterized by impairment of osteoclast action, and to improved techniques for isolation of osteoclasts and their precursors. This review will discuss some of these mechanisms.

AB - Our understanding of the molecular mechanisms responsible for osteoclast generation, differentiation, and bone resorption have improved dramatically in recent years. In part, this has been due to studies in osteopetrosis, the disease characterized by impairment of osteoclast action, and to improved techniques for isolation of osteoclasts and their precursors. This review will discuss some of these mechanisms.

KW - Apoptosis

KW - Cadherin

KW - Osteoclast

KW - Osteopetrosis

KW - Src

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DO - 10.1007/BF01768833

M3 - Article

AN - SCOPUS:0009687871

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JO - Journal of Bone and Mineral Metabolism

JF - Journal of Bone and Mineral Metabolism

SN - 0914-8779

IS - 2

ER -

Regulatory mechanisms of osteoclast differentiation and function

Abstract

Keywords

ASJC Scopus subject areas

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