TY - JOUR
T1 - Regulatory mechanisms controlling morphology and pathogenesis in Candida albicans
AU - Kadosh, David
N1 - Funding Information:
The author would like to thank Brian Wickes for critical reading of the manuscript and useful suggestions. Funding: this work was supported by the National Institutes of Health [grant numbers R01AI127692 , R21AI130668 , R21AI129883 ]. The content is solely the responsibility of the author and does not necessarily reflect the official views of the National Institutes of Health or the National Institute of Allergy and Infectious Diseases.
PY - 2019/12
Y1 - 2019/12
N2 - Candida albicans, a major human fungal pathogen, can cause a wide variety of both mucosal and systemic infections, particularly in immunocompromised individuals. Multiple lines of evidence suggest a strong association between virulence and the ability of C. albicans to undergo a reversible morphological transition from yeast to filamentous cells in response to host environmental cues. Most previous studies on mechanisms important for controlling the C. albicans morphological transition have focused on signaling pathways and sequence-specific transcription factors. However, in recent years a variety of novel mechanisms have been reported, including those involving global transcriptional regulation and translational control. A large-scale functional genomics screen has also revealed new roles in filamentation for certain key biosynthesis pathways. This review article will highlight several of these exciting recent discoveries and discuss how they are relevant to the development of novel antifungal strategies. Ultimately, components of mechanisms that control C. albicans morphogenesis and pathogenicity could potentially serve as viable antifungal targets.
AB - Candida albicans, a major human fungal pathogen, can cause a wide variety of both mucosal and systemic infections, particularly in immunocompromised individuals. Multiple lines of evidence suggest a strong association between virulence and the ability of C. albicans to undergo a reversible morphological transition from yeast to filamentous cells in response to host environmental cues. Most previous studies on mechanisms important for controlling the C. albicans morphological transition have focused on signaling pathways and sequence-specific transcription factors. However, in recent years a variety of novel mechanisms have been reported, including those involving global transcriptional regulation and translational control. A large-scale functional genomics screen has also revealed new roles in filamentation for certain key biosynthesis pathways. This review article will highlight several of these exciting recent discoveries and discuss how they are relevant to the development of novel antifungal strategies. Ultimately, components of mechanisms that control C. albicans morphogenesis and pathogenicity could potentially serve as viable antifungal targets.
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U2 - 10.1016/j.mib.2019.04.005
DO - 10.1016/j.mib.2019.04.005
M3 - Review article
C2 - 31129557
AN - SCOPUS:85065866161
VL - 52
SP - 27
EP - 34
JO - Current Opinion in Microbiology
JF - Current Opinion in Microbiology
SN - 1369-5274
ER -