Regulation of Th17 cells by P. UF1 against systemic Listeria monocytogenes infection

Natacha Colliou, Yong Ge, Minghao Gong, Mojgan Zadeh, Jing Li, Francis Alonzo, Mansour Mohamadzadeh

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Regulation of Th17 and Th1 cell responses against intracellular pathogens, including Listeria monocytogenes (L. m), is critical to limit inflammation-induced tissue damage. We recently demonstrated the ability of P. UF1 bacterium derived from the intestinal bacterial commensals of preterm infants fed human breast milk to significantly mitigate pathogen-induced inflammation limiting colonic tissue damage. Here we further elucidated the potential of P. UF1 to also regulate innate and T cells, particularly Th17 and Th1 cells, against systemic L. m infection. Data demonstrate that P. UF1 not only robustly regulated protective Th17 and Th1 cells, but also sustained regulatory T cells (Treg cells) resulting in accelerated L. m clearance. Together, regulation of pathogenic inflammation by a novel probiotic bacterium such as P. UF1 may illuminate a new strategy to specifically control Th17-Th1 cells via IL-10+ Treg cells to limit systemic tissue damage induced by intracellular pathogens, including L. m.

Original languageEnglish (US)
Pages (from-to)279-287
Number of pages9
JournalGut Microbes
Volume9
Issue number3
DOIs
StatePublished - 2018
Externally publishedYes

Keywords

  • Listeria monocytogenes
  • mucosal immunity
  • P. UF1 bacterium
  • regulatory T cells
  • SIGNR1
  • Th1 cells
  • Th17 cells

ASJC Scopus subject areas

  • Microbiology
  • Gastroenterology
  • Microbiology (medical)
  • Infectious Diseases

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