Regulation of Sleep and Growth Hormone in Adolescent Depression

RONALD E. DAHL, NEAL D. RYAN, DOUGLAS E. WILLIAMSON, PAUL J. AMBROSINI, HARRIS RABINOVICH, HANA NOVACENKO, BEVERLY NELSON, JOAQUIM PUIG-ANTICH

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

This article reviews findings of sleep, growth hormone (GH), and cortisol measures from a number of separate controlled studies of prepubertal and adolescent depression carried out by Puig-Antich and colleagues since 1978. New data are presented comparing 24-hour GH measures in adolescents with major depressive disorder (MDD) (N = 44; mean age = 14.8 ± 2.0) to normal control adolescents (N = 37; mean age = 15.3 ± 1.5). There were no significant overall group differences in summary GH measures between MDD and normal controls Splitting the MDD group on the basis of suicidality (definite plan or attempt) (N = 20), revealed a significant blunting of sleep GH compared to the nonsuicidal group (N = 24). These results are discussed in the context of the other sleep and neuroendocrine findings in this population, with evidence for dysregulation around sleep onset. The influences of development on sleep and GH regulation are also considered.

Original languageEnglish (US)
Pages (from-to)615-621
Number of pages7
JournalJournal of the American Academy of Child and Adolescent Psychiatry
Volume31
Issue number4
DOIs
StatePublished - Jan 1 1992

Keywords

  • adolescence
  • depression
  • growth hormone
  • sleep

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Psychiatry and Mental health

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