Regulation of Na+/K+ ATPase transport velocity by RNA editing

Claudia Colina, Juan Pablo Palavicini, Deepa Srikumar, Miguel Holmgren, Joshua J.C. Rosenthal

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


Because firing properties and metabolic rates vary widely, neurons require different transport rates from their Na+/K+ pumps in order to maintain ion homeostasis. In this study we show that Na+/K+ pump activity is tightly regulated by a novel process, RNA editing. Three codons within the squid Na+/K+ ATPase gene can be recoded at the RNA level, and the efficiency of conversion for each varies dramatically, and independently, between tissues. At one site, a highly conserved isoleucine in the seventh transmembrane span can be converted to a valine, a change that shifts the pump's intrinsic voltage dependence. Mechanistically, the removal of a single methyl group specifically targets the process of Na+ release to the extracellular solution, causing a higher turnover rate at the resting membrane potential.

Original languageEnglish (US)
Article numbere1000540
JournalPLoS biology
Issue number11
StatePublished - Nov 2010
Externally publishedYes

ASJC Scopus subject areas

  • General Immunology and Microbiology
  • General Biochemistry, Genetics and Molecular Biology
  • General Neuroscience
  • General Agricultural and Biological Sciences


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