Abstract
We and other workers have recently isolated three novel CC chemokines termed Exodus-1/LARC/Mip-3α, Exodus-2/6Ckine/SLC/TCA4, and Exodus-3/Mip- 3β/CKβ11/ELC. These chemokines share an amino terminal Asp-Cys-Cys-Leu sequence, unique among all chemokines. They also selectively regulate migration of adult T cells. Indeed, there is evidence that Exodus-2 and -3 are critical for adult T-cell adhesion to high endothelial venules in lymph nodes, a rate-limiting step for T-cell trafficking through nodal tissue. Less is known of the factors controlling migration of naive human fetal T cells. We tested whether these chemokines could regulate chemotaxis in cord blood T- cell populations, and compared that efficacy with normal peripheral blood adult T cells. The findings indicated that naive CD45RA + cord blood T-cell migration is stimulated by Exodus-2 and -3, and CD4 + cord blood T cells are attracted preferentially by Exodus-2 or -3 as compared with CD8+. Exodus-2 and -3 are likely to be critical in regulating the flux of naive CD4 + fetal T-cell population of secondary lymphoid tissue.
Original language | English (US) |
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Pages (from-to) | 269-273 |
Number of pages | 5 |
Journal | Immunology Letters |
Volume | 69 |
Issue number | 2 |
DOIs | |
State | Published - Aug 3 1999 |
Externally published | Yes |
Keywords
- CC Chemokine
- CD44
- CD45RA
- CD45RO
- Cord blood
- Exodus- 3/Mip-3β/CKβ11/ELC
- Exodus-1/LARC/Mip-3α
- Exodus-2/6Ckine/SLC/TCA4
- Naive fetal T-cell migration
- T-cell ontogeny
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology