Regulation of naive fetal T-cell migration by the chemokines Exodus-2 and Exodus-3

Kent Christopherson, Zacharie Brahmi, Robert Hromas

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We and other workers have recently isolated three novel CC chemokines termed Exodus-1/LARC/Mip-3α, Exodus-2/6Ckine/SLC/TCA4, and Exodus-3/Mip- 3β/CKβ11/ELC. These chemokines share an amino terminal Asp-Cys-Cys-Leu sequence, unique among all chemokines. They also selectively regulate migration of adult T cells. Indeed, there is evidence that Exodus-2 and -3 are critical for adult T-cell adhesion to high endothelial venules in lymph nodes, a rate-limiting step for T-cell trafficking through nodal tissue. Less is known of the factors controlling migration of naive human fetal T cells. We tested whether these chemokines could regulate chemotaxis in cord blood T- cell populations, and compared that efficacy with normal peripheral blood adult T cells. The findings indicated that naive CD45RA + cord blood T-cell migration is stimulated by Exodus-2 and -3, and CD4 + cord blood T cells are attracted preferentially by Exodus-2 or -3 as compared with CD8+. Exodus-2 and -3 are likely to be critical in regulating the flux of naive CD4 + fetal T-cell population of secondary lymphoid tissue.

Original languageEnglish (US)
Pages (from-to)269-273
Number of pages5
JournalImmunology Letters
Volume69
Issue number2
DOIs
StatePublished - Aug 3 1999
Externally publishedYes

Keywords

  • CC Chemokine
  • CD44
  • CD45RA
  • CD45RO
  • Cord blood
  • Exodus- 3/Mip-3β/CKβ11/ELC
  • Exodus-1/LARC/Mip-3α
  • Exodus-2/6Ckine/SLC/TCA4
  • Naive fetal T-cell migration
  • T-cell ontogeny

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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