Regulation of mRNA translation in renal physiology and disease

Balakuntalam S. Kasinath, Denis Feliers, Kavithalakshmi Sataranatarajan, Goutam Ghosh Choudhury, Myung Ja Lee, Meenalakshmi M. Mariappan

Research output: Contribution to journalReview article

41 Scopus citations

Abstract

Translation, a process of generating a peptide from the codons present in messenger RNA, can be a site of independent regulation of protein synthesis; it has not been well studied in the kidney. Translation occurs in three stages (initiation, elongation, and termination), each with its own set of regulatory factors. Mechanisms controlling translation include small inhibitory RNAs such as microRNAs, binding proteins, and signaling reactions. Role of translation in renal injury in diabetes, endoplasmic reticulum stress, acute kidney injury, and, in physiological adaptation to loss of nephrons is reviewed here. Contribution of mRNA translation to physiology and disease is not well understood. Because it is involved in such diverse areas as development and cancer, it should prove a fertile field for investigation in renal science.

Original languageEnglish (US)
Pages (from-to)F1153-F1165
JournalAmerican Journal of Physiology - Renal Physiology
Volume297
Issue number5
DOIs
StatePublished - Nov 2009

Keywords

  • Compensatory renal hypertrophy
  • Diabetic nephropathy
  • Endoplasmic reticulum stress
  • Protein synthesis
  • Signaling regulation

ASJC Scopus subject areas

  • Physiology
  • Urology

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    Kasinath, B. S., Feliers, D., Sataranatarajan, K., Choudhury, G. G., Lee, M. J., & Mariappan, M. M. (2009). Regulation of mRNA translation in renal physiology and disease. American Journal of Physiology - Renal Physiology, 297(5), F1153-F1165. https://doi.org/10.1152/ajprenal.90748.2008