Regulation of mammalian target of rapamycin complex 1 (mTORC1) by hypoxia: Causes and consequences

Research output: Contribution to journalReview article

18 Scopus citations

Abstract

Integration of cellular and extracellular signals maintains tissue homeostasis under conditions of normal proliferation and stress. A central player in regulating responses to stress is the serine/threonine kinase mammalian target of rapamycin (mTOR). In many cancers, mTOR complex 1 (mTORC1) signaling is enhanced, even under conditions where such signaling should be suppressed. This article reviews some of the details that are emerging on how low oxygen (hypoxia) regulates mTORC1 signaling, and the consequences for dysregulation in pediatric solid tumors.

Original languageEnglish (US)
Pages (from-to)95-102
Number of pages8
JournalTargeted Oncology
Volume6
Issue number2
DOIs
StatePublished - Jun 2011
Externally publishedYes

Keywords

  • Hypoxia
  • Pediatric malignancies
  • mTORC1 signaling

ASJC Scopus subject areas

  • Oncology
  • Cancer Research
  • Pharmacology (medical)

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