Regulation of intestinal IgA responses

Na Xiong, Shaomin Hu

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

The intestine harbors enormous numbers of commensal bacteria and is under frequent attack from food-borne pathogens and toxins. A properly regulated immune response is critical for homeostatic maintenance of commensals and for protection against infection and toxins in the intestine. Immunoglobulin A (IgA) isotype antibodies function specifically in mucosal sites such as the intestines to help maintain intestinal health by binding to and regulating commensal microbiota, pathogens and toxins. IgA antibodies are produced by intestinal IgA antibody-secreting plasma cells generated in gut-associated lymphoid tissues from naïve B cells in response to stimulations of the intestinal bacteria and components. Research on generation, migration, and maintenance of IgA-secreting cells is important in our effort to understand the biology of IgA responses and to help better design vaccines against intestinal infections.

Original languageEnglish (US)
Pages (from-to)2645-2655
Number of pages11
JournalCellular and Molecular Life Sciences
Volume72
Issue number14
DOIs
StatePublished - Jul 24 2015
Externally publishedYes

Keywords

  • Chemokine receptor
  • Follicular T helper cells
  • IgA antibody
  • IgA antibody-secreting plasma cells
  • IgA memory
  • Migration and localization

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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