Abstract
We compared the effects of calorie restriction (CR) and cyclophosphamide (CTX) on the progression of lupus nephritis and immunological changes in NZB/NZW F1 mice. Ad libitum (AL)/CTX and CR delayed onset of proteinuria and significantly decreased serum levels of anti-dsDNA, anti-histone, and circulating immune complex antibodies. CTX and CR prevented the increase in and activation of B cells, the decline in CD8+ T cells, and maintained a higher proportion of naïve CD4+ and CD8+ cells. MHC class I antigen and LFA-1 expression on CD8+ T cells and MHC class II antigen on B cells were also decreased. AL/CTX and CR prevented the increase in production of IL-10 and up-regulated IL-2 production in T cells ex vivo. We concluded that both CR and CTX can delay the onset of autoimmune disease, in part by maintaining higher numbers of naïve T cells and the immune responsiveness of T cells and decreasing the proportion of B cells.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 54-65 |
| Number of pages | 12 |
| Journal | Cellular Immunology |
| Volume | 228 |
| Issue number | 1 |
| DOIs | |
| State | Published - Mar 2004 |
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Keywords
- Calorie restriction
- Cyclophosphamide
- Cytokines
- SLE
- T cells
ASJC Scopus subject areas
- Cell Biology
- Immunology
Cite this
Regulation of immune function by calorie restriction and cyclophosphamide treatment in lupus-prone NZB/NZW F1 mice. / Sun, Dongxu; Krishnan, Aparna; Su, Jianrong; Lawrence, Richard; Zaman, Khaliquz; Fernandes, Gabriel.
In: Cellular Immunology, Vol. 228, No. 1, 03.2004, p. 54-65.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Regulation of immune function by calorie restriction and cyclophosphamide treatment in lupus-prone NZB/NZW F1 mice
AU - Sun, Dongxu
AU - Krishnan, Aparna
AU - Su, Jianrong
AU - Lawrence, Richard
AU - Zaman, Khaliquz
AU - Fernandes, Gabriel
PY - 2004/3
Y1 - 2004/3
N2 - We compared the effects of calorie restriction (CR) and cyclophosphamide (CTX) on the progression of lupus nephritis and immunological changes in NZB/NZW F1 mice. Ad libitum (AL)/CTX and CR delayed onset of proteinuria and significantly decreased serum levels of anti-dsDNA, anti-histone, and circulating immune complex antibodies. CTX and CR prevented the increase in and activation of B cells, the decline in CD8+ T cells, and maintained a higher proportion of naïve CD4+ and CD8+ cells. MHC class I antigen and LFA-1 expression on CD8+ T cells and MHC class II antigen on B cells were also decreased. AL/CTX and CR prevented the increase in production of IL-10 and up-regulated IL-2 production in T cells ex vivo. We concluded that both CR and CTX can delay the onset of autoimmune disease, in part by maintaining higher numbers of naïve T cells and the immune responsiveness of T cells and decreasing the proportion of B cells.
AB - We compared the effects of calorie restriction (CR) and cyclophosphamide (CTX) on the progression of lupus nephritis and immunological changes in NZB/NZW F1 mice. Ad libitum (AL)/CTX and CR delayed onset of proteinuria and significantly decreased serum levels of anti-dsDNA, anti-histone, and circulating immune complex antibodies. CTX and CR prevented the increase in and activation of B cells, the decline in CD8+ T cells, and maintained a higher proportion of naïve CD4+ and CD8+ cells. MHC class I antigen and LFA-1 expression on CD8+ T cells and MHC class II antigen on B cells were also decreased. AL/CTX and CR prevented the increase in production of IL-10 and up-regulated IL-2 production in T cells ex vivo. We concluded that both CR and CTX can delay the onset of autoimmune disease, in part by maintaining higher numbers of naïve T cells and the immune responsiveness of T cells and decreasing the proportion of B cells.
KW - Calorie restriction
KW - Cyclophosphamide
KW - Cytokines
KW - SLE
KW - T cells
UR - http://www.scopus.com/inward/record.url?scp=2942618696&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=2942618696&partnerID=8YFLogxK
U2 - 10.1016/j.cellimm.2004.04.001
DO - 10.1016/j.cellimm.2004.04.001
M3 - Article
C2 - 15203320
AN - SCOPUS:2942618696
VL - 228
SP - 54
EP - 65
JO - Cellular Immunology
JF - Cellular Immunology
SN - 0008-8749
IS - 1
ER -