Regulation of immune function by calorie restriction and cyclophosphamide treatment in lupus-prone NZB/NZW F1 mice

Dongxu Sun, Aparna Krishnan, Jianrong Su, Richard Lawrence, Khaliquz Zaman, Gabriel Fernandes

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

We compared the effects of calorie restriction (CR) and cyclophosphamide (CTX) on the progression of lupus nephritis and immunological changes in NZB/NZW F1 mice. Ad libitum (AL)/CTX and CR delayed onset of proteinuria and significantly decreased serum levels of anti-dsDNA, anti-histone, and circulating immune complex antibodies. CTX and CR prevented the increase in and activation of B cells, the decline in CD8+ T cells, and maintained a higher proportion of naïve CD4+ and CD8+ cells. MHC class I antigen and LFA-1 expression on CD8+ T cells and MHC class II antigen on B cells were also decreased. AL/CTX and CR prevented the increase in production of IL-10 and up-regulated IL-2 production in T cells ex vivo. We concluded that both CR and CTX can delay the onset of autoimmune disease, in part by maintaining higher numbers of naïve T cells and the immune responsiveness of T cells and decreasing the proportion of B cells.

Original languageEnglish (US)
Pages (from-to)54-65
Number of pages12
JournalCellular Immunology
Volume228
Issue number1
DOIs
StatePublished - Mar 1 2004

Keywords

  • Calorie restriction
  • Cyclophosphamide
  • Cytokines
  • SLE
  • T cells

ASJC Scopus subject areas

  • Immunology

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