Abstract
We compared the effects of calorie restriction (CR) and cyclophosphamide (CTX) on the progression of lupus nephritis and immunological changes in NZB/NZW F1 mice. Ad libitum (AL)/CTX and CR delayed onset of proteinuria and significantly decreased serum levels of anti-dsDNA, anti-histone, and circulating immune complex antibodies. CTX and CR prevented the increase in and activation of B cells, the decline in CD8+ T cells, and maintained a higher proportion of naïve CD4+ and CD8+ cells. MHC class I antigen and LFA-1 expression on CD8+ T cells and MHC class II antigen on B cells were also decreased. AL/CTX and CR prevented the increase in production of IL-10 and up-regulated IL-2 production in T cells ex vivo. We concluded that both CR and CTX can delay the onset of autoimmune disease, in part by maintaining higher numbers of naïve T cells and the immune responsiveness of T cells and decreasing the proportion of B cells.
Original language | English (US) |
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Pages (from-to) | 54-65 |
Number of pages | 12 |
Journal | Cellular Immunology |
Volume | 228 |
Issue number | 1 |
DOIs | |
State | Published - Mar 2004 |
Keywords
- Calorie restriction
- Cyclophosphamide
- Cytokines
- SLE
- T cells
ASJC Scopus subject areas
- Immunology