Regulation of firing of dopaminergic neurons and control of goal-directed behaviors

Anthony A. Grace, Stan B. Floresco, Yukiori Goto, Daniel J Lodge

Research output: Contribution to journalArticle

651 Citations (Scopus)

Abstract

There are several brain regions that have been implicated in the control of motivated behavior and whose disruption leads to the pathophysiology observed in major psychiatric disorders. These systems include the ventral hippocampus, which is involved in context and focus on tasks, the amygdala, which mediates emotional behavior, and the prefrontal cortex, which modulates activity throughout the limbic system to enable behavioral flexibility. Each of these systems has overlapping projections to the nucleus accumbens, where these inputs are integrated under the modulatory influence of dopamine. Here, we provide a systems-oriented approach to interpreting the function of the dopamine system, its modulation of limbic-cortical interactions and how disruptions within this system might underlie the pathophysiology of schizophrenia and drug abuse.

Original languageEnglish (US)
Pages (from-to)220-227
Number of pages8
JournalTrends in Neurosciences
Volume30
Issue number5
DOIs
StatePublished - May 2007
Externally publishedYes

Fingerprint

Dopaminergic Neurons
Dopamine
Limbic System
Behavior Control
Nucleus Accumbens
Systems Analysis
Amygdala
Prefrontal Cortex
Substance-Related Disorders
Psychiatry
Hippocampus
Schizophrenia
Brain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Regulation of firing of dopaminergic neurons and control of goal-directed behaviors. / Grace, Anthony A.; Floresco, Stan B.; Goto, Yukiori; Lodge, Daniel J.

In: Trends in Neurosciences, Vol. 30, No. 5, 05.2007, p. 220-227.

Research output: Contribution to journalArticle

Grace, Anthony A. ; Floresco, Stan B. ; Goto, Yukiori ; Lodge, Daniel J. / Regulation of firing of dopaminergic neurons and control of goal-directed behaviors. In: Trends in Neurosciences. 2007 ; Vol. 30, No. 5. pp. 220-227.
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