Regulation of DNA duplication by the mTOR signaling pathway

Zhengfu He, Peter J. Houghton, Terence M. Williams, Changxian Shen

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Accurate and complete DNA replication and separation are essential for genetic information inheritance and organism maintenance. Errors in DNA duplication are the main source of genetic instability. Understanding DNA duplication regulation is the key to elucidate the mechanisms and find treatment strategies for human genetic disorders, especially cancer. The mechanistic target of rapamycin (mTOR) is a central regulator of cell growth and proliferation by integrating and processing extracellular and intracellular signals to monitor the well-being of cell physiology. mTOR signaling dysregulation is associated with many human diseases including cancer and diabetes. Emerging evidence has demonstrated that mTOR signaling plays a key role in DNA duplication. We herein review the current knowledge of mTOR signaling in the regulation of DNA replication origin licensing, replication fork progression, and stabilization.

Original languageEnglish (US)
Pages (from-to)742-751
Number of pages10
JournalCell Cycle
Volume20
Issue number8
DOIs
StatePublished - 2021

Keywords

  • DNA repair
  • cell cycle
  • mTOR; DNA replication origin licensing
  • replication fork progression
  • replication fork stabilization

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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