Regulation of differentiation in normal and transformed erythroid cells

Richard A. Rifkind, Paul A. Marks, Arthur Bank, Masaaiki Terada, Roberta C. Reuben, George M. Maniatis, Eitan Fibach, Uri Nudel, Jane E. Salmon, Yair Gazitt

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Studies are described employing two erythropoietic systems to elucidate regulatory mechanisms that control both normal erythropoiesis and erythroid differentiation of transformed hemopoietic precursors. Evidence is provided suggesting that normal erythroid cell precursors require erythropoietin as a growth factor that regulates the number of precursors capable of differentiating. Murine erythroleukemia cells proliferate without need of erythropoietin; they show a variable, generally low, rate of spontaneous differentiation and a brisk rate of erythropoiesis in response to a variety of chemical agents. Present studies suggest that these chemical inducers initiate a series of events including cell surface related changes, alterations in cell cycle kinetics, and modifications of chromatin and DNA structure which result in the irreversible commitment of these leukemia cells to erythroid differentiation and the synthesis of red-cell-specific products.

Original languageEnglish (US)
Pages (from-to)155-161
Number of pages7
JournalIn Vitro
Volume14
Issue number1
DOIs
StatePublished - Jan 1978
Externally publishedYes

Keywords

  • differentiation
  • erythroleukemia
  • erythropoiesis
  • erythropoietin
  • Friend cell

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology

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