Regulation of dendritic cell function by vitamin D

Myriam Barragan, Misty Good, Jay K. Kolls

Research output: Contribution to journalReview article

80 Scopus citations

Abstract

Studies over the last two decades have revealed profound immunomodulatory aspects of vitamin D on various aspects of the immune system. This review will provide an overview of Vitamin D metabolism, a description of dendritic cell subsets, and highlight recent advances on the effects of vitamin D on dendritic cell function, maturation, cytokine production and antigen presentation. The active form of vitamin D, 1,25(OH)2D3, has important immunoregulatory and anti-inflammatory effects. Specifically, the 1,25(OH)2D3-Vitamin D3 complex can affect the maturation and migration of many dendritic cell subsets, conferring a special immunoregulatory role as well as tolerogenic properties affecting cytokine and chemokine production. Furthermore, there have been many recent studies demonstrating the effects of Vitamin D on allergic disease and autoimmunity. A clear understanding of the effects of the various forms of Vitamin D will provide new opportunities to improve human health.

Original languageEnglish (US)
Pages (from-to)8127-8151
Number of pages25
JournalNutrients
Volume7
Issue number9
DOIs
StatePublished - 2015
Externally publishedYes

Keywords

  • Cytokines
  • Dendritic cells
  • Inflammation
  • Innate and adaptive immunity
  • Interleukins
  • Vitamin D
  • Vitamin D receptor

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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