Abstract
Studies over the last two decades have revealed profound immunomodulatory aspects of vitamin D on various aspects of the immune system. This review will provide an overview of Vitamin D metabolism, a description of dendritic cell subsets, and highlight recent advances on the effects of vitamin D on dendritic cell function, maturation, cytokine production and antigen presentation. The active form of vitamin D, 1,25(OH)2D3, has important immunoregulatory and anti-inflammatory effects. Specifically, the 1,25(OH)2D3-Vitamin D3 complex can affect the maturation and migration of many dendritic cell subsets, conferring a special immunoregulatory role as well as tolerogenic properties affecting cytokine and chemokine production. Furthermore, there have been many recent studies demonstrating the effects of Vitamin D on allergic disease and autoimmunity. A clear understanding of the effects of the various forms of Vitamin D will provide new opportunities to improve human health.
Original language | English (US) |
---|---|
Pages (from-to) | 8127-8151 |
Number of pages | 25 |
Journal | Nutrients |
Volume | 7 |
Issue number | 9 |
DOIs | |
State | Published - 2015 |
Externally published | Yes |
Keywords
- Cytokines
- Dendritic cells
- Inflammation
- Innate and adaptive immunity
- Interleukins
- Vitamin D
- Vitamin D receptor
ASJC Scopus subject areas
- Food Science
- Nutrition and Dietetics