Regulation of colony stimulating factor-1 (CSF-1) in endometrial cells: glucocorticoids and oxidative stress regulate the expression of CSF-1 and its receptor c-fms in endometrial cells

Kiran Gill, Nameer B Kirma, Vijaya Sudha Gunna, Nalini Santanam, Sampath Parthasarathy, Rajeshwar R Tekmal

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: To evaluate the regulation and expression of CSF-1 and its receptor c-fms in endometrial cells. Design: In vitro study. Setting: Research and teaching institution. Patient(s): None.Intervention(s): In vitro experimental study. Main Outcome Measure(s): The effect of glucocorticoid and oxidative stress on the expression of CSF-1 and c-fms in endometrial cells. Result(s): Cultured nonmalignant EM42 cells not only express CSF-1 and c-fms but are also capable of responding to exogenous CSF-1. We have also seen that glucocorticoids can regulate the expression of CSF-1/c-fms in endometrial cells. Furthermore, this study shows that oxidative stress plays a significant role in the induction of CSF-1 and its receptor c-fms. Conclusion(s): The results suggest that CSF-1 may promote the growth of nonmalignant endometrial cells in both an autocrine and paracrine manner and that endometrial cells under oxidative stress induce CSF-1 and c-fms.

Original languageEnglish (US)
Pages (from-to)1005-1011
Number of pages7
JournalFertility and Sterility
Volume76
Issue number5
DOIs
StatePublished - 2001
Externally publishedYes

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Macrophage Colony-Stimulating Factor
Glucocorticoids
Oxidative Stress
Teaching
Outcome Assessment (Health Care)
Growth
Research

Keywords

  • c-fms
  • CSF-1
  • Endometriosis
  • Glucocorticoids
  • Oxidative stress

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Regulation of colony stimulating factor-1 (CSF-1) in endometrial cells : glucocorticoids and oxidative stress regulate the expression of CSF-1 and its receptor c-fms in endometrial cells. / Gill, Kiran; Kirma, Nameer B; Gunna, Vijaya Sudha; Santanam, Nalini; Parthasarathy, Sampath; Tekmal, Rajeshwar R.

In: Fertility and Sterility, Vol. 76, No. 5, 2001, p. 1005-1011.

Research output: Contribution to journalArticle

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AU - Parthasarathy, Sampath

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AB - Objective: To evaluate the regulation and expression of CSF-1 and its receptor c-fms in endometrial cells. Design: In vitro study. Setting: Research and teaching institution. Patient(s): None.Intervention(s): In vitro experimental study. Main Outcome Measure(s): The effect of glucocorticoid and oxidative stress on the expression of CSF-1 and c-fms in endometrial cells. Result(s): Cultured nonmalignant EM42 cells not only express CSF-1 and c-fms but are also capable of responding to exogenous CSF-1. We have also seen that glucocorticoids can regulate the expression of CSF-1/c-fms in endometrial cells. Furthermore, this study shows that oxidative stress plays a significant role in the induction of CSF-1 and its receptor c-fms. Conclusion(s): The results suggest that CSF-1 may promote the growth of nonmalignant endometrial cells in both an autocrine and paracrine manner and that endometrial cells under oxidative stress induce CSF-1 and c-fms.

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