Regulation of cell-type-specific transcription and differentiation of the pituitary

Zelton D Sharp, Zhaodan Cao

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The transcription of rat prolactin and growth hormone genes in vitro requires a pituitary transcription factor, specific to certain cell types in the pituitary, which currently appears to be the PUF-I/Pit-1/GHF-1 protein. This factor binds to cis-regulatory elements in the 5′ region of both genes and exerts a positive influence on transcription initiation presumably by interacting with general transcription factors. The PUF-I/Pit-1/GHF-1 transcriptional regulatory protein probably has an important role in not only the differentiation of the pituitary lactotroph/somatotroph cell lineage; it is also expressed in the early development of the nervous system but its function there is less well documented. It appears to be one member of a family of trans-activator proteins involved in differential gene expression in several cell types.

Original languageEnglish (US)
Pages (from-to)80-85
Number of pages6
JournalBioEssays
Volume12
Issue number2
StatePublished - 1990
Externally publishedYes

Fingerprint

Transcription
transcription (genetics)
Cells
transcription factors
Genes
General Transcription Factors
Lactotrophs
Somatotrophs
regulatory sequences
Proteins
Trans-Activators
regulatory proteins
Neurology
Cell Lineage
cells
prolactin
Gene expression
nervous system
Prolactin
somatotropin

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Biochemistry
  • Cell Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Developmental Biology
  • Agricultural and Biological Sciences (miscellaneous)
  • Plant Science

Cite this

Regulation of cell-type-specific transcription and differentiation of the pituitary. / Sharp, Zelton D; Cao, Zhaodan.

In: BioEssays, Vol. 12, No. 2, 1990, p. 80-85.

Research output: Contribution to journalArticle

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