TY - JOUR
T1 - Regulation of cancer cell glucose metabolism is determinant for cancer cell fate after melatonin administration
AU - Rodríguez, Carmen
AU - Puente-Moncada, Noelia
AU - Reiter, Russel J.
AU - Sánchez-Sánchez, Ana M.
AU - Herrera, Federico
AU - Rodríguez-Blanco, Jezabel
AU - Duarte-Olivenza, Cristina
AU - Turos-Cabal, María
AU - Antolín, Isaac
AU - Martín, Vanesa
N1 - Publisher Copyright:
© 2020 Wiley Periodicals LLC
PY - 2021/1
Y1 - 2021/1
N2 - Several oncogenic pathways plus local microenvironmental conditions, such as hypoxia, converge on the regulation of cancer cells metabolism. The major metabolic alteration consists of a shift from oxidative phosphorylation as the major glucose consumer to aerobic glycolysis, although most of cancer cells utilize both pathways to a greater or lesser extent. Aerobic glycolysis, together with the directly related metabolic pathways such as the tricarboxylic acid cycle, the pentose phosphate pathway, or gluconeogenesis are currently considered as therapeutic targets in cancer research. Melatonin has been reported to present numerous antitumor effects, which result in a reduced cell growth. This is achieved with both low and high concentrations with no relevant side effects. Indeed, high concentrations of this indolamine reduce proliferation of cancer types resistant to low concentrations and induce cell death in some types of tumors. Previous work suggest that regulation of glucose metabolism and other related pathways play an important role in the antitumoral effects of high concentration of melatonin. In the present review, we analyze recent work on the regulation by such concentrations of this indolamine on aerobic glycolysis, gluconeogenesis, the tricarboxylic acid cycle and the pentose phosphate pathways of cancer cells.
AB - Several oncogenic pathways plus local microenvironmental conditions, such as hypoxia, converge on the regulation of cancer cells metabolism. The major metabolic alteration consists of a shift from oxidative phosphorylation as the major glucose consumer to aerobic glycolysis, although most of cancer cells utilize both pathways to a greater or lesser extent. Aerobic glycolysis, together with the directly related metabolic pathways such as the tricarboxylic acid cycle, the pentose phosphate pathway, or gluconeogenesis are currently considered as therapeutic targets in cancer research. Melatonin has been reported to present numerous antitumor effects, which result in a reduced cell growth. This is achieved with both low and high concentrations with no relevant side effects. Indeed, high concentrations of this indolamine reduce proliferation of cancer types resistant to low concentrations and induce cell death in some types of tumors. Previous work suggest that regulation of glucose metabolism and other related pathways play an important role in the antitumoral effects of high concentration of melatonin. In the present review, we analyze recent work on the regulation by such concentrations of this indolamine on aerobic glycolysis, gluconeogenesis, the tricarboxylic acid cycle and the pentose phosphate pathways of cancer cells.
KW - TCA cycle
KW - aerobic glycolysis
KW - gluconeogenesis
KW - melatonin cytotoxicity
KW - pentose phosphate pathway
KW - tumor metabolism
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U2 - 10.1002/jcp.29886
DO - 10.1002/jcp.29886
M3 - Review article
C2 - 32725819
AN - SCOPUS:85088655129
SN - 0021-9541
VL - 236
SP - 27
EP - 40
JO - Journal of Cellular Physiology
JF - Journal of Cellular Physiology
IS - 1
ER -