TY - JOUR
T1 - Regulation of adrenocortical cell proliferation in culture
AU - Hornsby, Peter J.
N1 - Funding Information:
Acknowlednments Original work from the author's laboratory reviewed in this article was supported by NIH Research Grants AG 00936 and CA 32468.
PY - 1984
Y1 - 1984
N2 - The regulation of the proliferation of adrenocortical cells in culture is reviewed. The hormones and growth factors affecting adrenocortical proliferation in culture and their physiological relevance are discussed. The following general conclusions are made: (i) ACTH is growth-stimulatory in vivo, but directly replication-inhibitory both in culture and in vivo, and is therefore an indirect mitogen. (ii) Insulin, IGFs, some pituitary and brain growth factors, and other unknown factors in serum, stimulate growth in culture, but their role in control of adrenocortical size in vivo is unknown. (iii) Pure, known pituitary hormones, other than ACTH, have no effect on adrenocortical proliferation in culture. (iv) Angiotensin is mitogenic in culture and perhaps also in vivo under some circumstances.
AB - The regulation of the proliferation of adrenocortical cells in culture is reviewed. The hormones and growth factors affecting adrenocortical proliferation in culture and their physiological relevance are discussed. The following general conclusions are made: (i) ACTH is growth-stimulatory in vivo, but directly replication-inhibitory both in culture and in vivo, and is therefore an indirect mitogen. (ii) Insulin, IGFs, some pituitary and brain growth factors, and other unknown factors in serum, stimulate growth in culture, but their role in control of adrenocortical size in vivo is unknown. (iii) Pure, known pituitary hormones, other than ACTH, have no effect on adrenocortical proliferation in culture. (iv) Angiotensin is mitogenic in culture and perhaps also in vivo under some circumstances.
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U2 - 10.1080/07435808409036501
DO - 10.1080/07435808409036501
M3 - Article
C2 - 6100245
AN - SCOPUS:0021590997
SN - 0743-5800
VL - 10
SP - 259
EP - 281
JO - Endocrine Research
JF - Endocrine Research
IS - 3-4
ER -