TY - JOUR
T1 - Regulation of adiponectin multimerization, signaling and function
AU - Liu, Meilian
AU - Liu, Feng
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2014/1
Y1 - 2014/1
N2 - Adiponectin, which exists in serum in three major complexes including trimer, hexamer, and the high molecular weight (HMW) form, has strong insulin sensitizing, anti-inflammatory and anti-diabetic functions. Different adiponectin complexes exert tissue-specific biological functions and activate distinct signaling pathways. In this review, we summarize our current understanding on the mechanisms regulating adiponectin multimerization. We also describe the major target tissues in which distinct adiponectin multimers exert their functional roles. Finally, we discuss the potential involvement of endoplasmic reticulum stress and mitochondrial stress in diet-induced adiponectin downregulation and highlight the roles of Disulfide bond A oxidoreductase-like protein (DsbA-L) in the prevention of endoplasmic reticulum stress and promotion of adiponectin multimerization, stability, and function.
AB - Adiponectin, which exists in serum in three major complexes including trimer, hexamer, and the high molecular weight (HMW) form, has strong insulin sensitizing, anti-inflammatory and anti-diabetic functions. Different adiponectin complexes exert tissue-specific biological functions and activate distinct signaling pathways. In this review, we summarize our current understanding on the mechanisms regulating adiponectin multimerization. We also describe the major target tissues in which distinct adiponectin multimers exert their functional roles. Finally, we discuss the potential involvement of endoplasmic reticulum stress and mitochondrial stress in diet-induced adiponectin downregulation and highlight the roles of Disulfide bond A oxidoreductase-like protein (DsbA-L) in the prevention of endoplasmic reticulum stress and promotion of adiponectin multimerization, stability, and function.
KW - DsbA-L
KW - ER stress
KW - adiponectin
KW - adiponectin multimerization
KW - adiponectin multimers
UR - http://www.scopus.com/inward/record.url?scp=85047686926&partnerID=8YFLogxK
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U2 - 10.1016/j.beem.2013.06.003
DO - 10.1016/j.beem.2013.06.003
M3 - Article
C2 - 24417943
AN - SCOPUS:85047686926
VL - 28
SP - 25
EP - 31
JO - Best Practice and Research in Clinical Endocrinology and Metabolism
JF - Best Practice and Research in Clinical Endocrinology and Metabolism
SN - 1521-690X
IS - 1
ER -