Regulation Effects of Angiostatin on the Mouse Blastocysts

Tian Fu Zhao; Jian Zhang; Jing Li; Yu Jing Cao; Su Min Li; Jia Xi Zhou; Fu Yang Li; Li Bo Yao; En Kui Duan

Regulation Effects of Angiostatin on the Mouse Blastocysts

Tian Fu Zhao, Jian Zhang, Jing Li, Yu Jing Cao, Su Min Li, Jia Xi Zhou, Fu Yang Li, Li Bo Yao, En Kui Duan

Greehey Children's Cancer Research Institute

Research output: Contribution to journal › Article › peer-review

Abstract

Angiostatin, a 38 ku fragment encompassing the four kringle region of plasminogen, has been identified and characterized to be a potent inhibitor of neovascularization and tumor metastasis. There is a strikingly similarity between tumor metastasis and embryo implantation. However, effect of angiostatin in the mouse blastocyst has never been reported. The results showed for the first time that angiostatin down-regulated the expression of matrix metalloproteinase-2 (MMP-2), MMP-9, vascular endothelial growth factor family and its receptor, KDR, and up-regulated the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 expression by binding with integrin αVβ3, suggesting that angiostatin may play a role in embryo implantation.

Original language	English (US)
Pages (from-to)	778-783
Number of pages	6
Journal	Progress in Biochemistry and Biophysics
Volume	30
Issue number	5
State	Published - Oct 2003

Keywords

Angiostatin
Blastocyst
Integrin
Matrix metalloproteinases (MMPs)
TIMPs

ASJC Scopus subject areas

Biophysics
Biochemistry

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title = "Regulation Effects of Angiostatin on the Mouse Blastocysts",

abstract = "Angiostatin, a 38 ku fragment encompassing the four kringle region of plasminogen, has been identified and characterized to be a potent inhibitor of neovascularization and tumor metastasis. There is a strikingly similarity between tumor metastasis and embryo implantation. However, effect of angiostatin in the mouse blastocyst has never been reported. The results showed for the first time that angiostatin down-regulated the expression of matrix metalloproteinase-2 (MMP-2), MMP-9, vascular endothelial growth factor family and its receptor, KDR, and up-regulated the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 expression by binding with integrin αVβ3, suggesting that angiostatin may play a role in embryo implantation.",

keywords = "Angiostatin, Blastocyst, Integrin, Matrix metalloproteinases (MMPs), TIMPs",

author = "Zhao, {Tian Fu} and Jian Zhang and Jing Li and Cao, {Yu Jing} and Li, {Su Min} and Zhou, {Jia Xi} and Li, {Fu Yang} and Yao, {Li Bo} and Duan, {En Kui}",

year = "2003",

month = oct,

language = "English (US)",

volume = "30",

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journal = "Progress in Biochemistry and Biophysics",

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publisher = "Science Press",

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TY - JOUR

T1 - Regulation Effects of Angiostatin on the Mouse Blastocysts

AU - Zhao, Tian Fu

AU - Zhang, Jian

AU - Li, Jing

AU - Cao, Yu Jing

AU - Li, Su Min

AU - Zhou, Jia Xi

AU - Li, Fu Yang

AU - Yao, Li Bo

AU - Duan, En Kui

PY - 2003/10

Y1 - 2003/10

N2 - Angiostatin, a 38 ku fragment encompassing the four kringle region of plasminogen, has been identified and characterized to be a potent inhibitor of neovascularization and tumor metastasis. There is a strikingly similarity between tumor metastasis and embryo implantation. However, effect of angiostatin in the mouse blastocyst has never been reported. The results showed for the first time that angiostatin down-regulated the expression of matrix metalloproteinase-2 (MMP-2), MMP-9, vascular endothelial growth factor family and its receptor, KDR, and up-regulated the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 expression by binding with integrin αVβ3, suggesting that angiostatin may play a role in embryo implantation.

AB - Angiostatin, a 38 ku fragment encompassing the four kringle region of plasminogen, has been identified and characterized to be a potent inhibitor of neovascularization and tumor metastasis. There is a strikingly similarity between tumor metastasis and embryo implantation. However, effect of angiostatin in the mouse blastocyst has never been reported. The results showed for the first time that angiostatin down-regulated the expression of matrix metalloproteinase-2 (MMP-2), MMP-9, vascular endothelial growth factor family and its receptor, KDR, and up-regulated the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 expression by binding with integrin αVβ3, suggesting that angiostatin may play a role in embryo implantation.

KW - Angiostatin

KW - Blastocyst

KW - Integrin

KW - Matrix metalloproteinases (MMPs)

KW - TIMPs

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