Regulation Effects of Angiostatin on the Mouse Blastocysts

Tian Fu Zhao, Jian Zhang, Jing Li, Yu Jing Cao, Su Min Li, Jia Xi Zhou, Fu Yang Li, Li Bo Yao, En Kui Duan

Research output: Contribution to journalArticlepeer-review


Angiostatin, a 38 ku fragment encompassing the four kringle region of plasminogen, has been identified and characterized to be a potent inhibitor of neovascularization and tumor metastasis. There is a strikingly similarity between tumor metastasis and embryo implantation. However, effect of angiostatin in the mouse blastocyst has never been reported. The results showed for the first time that angiostatin down-regulated the expression of matrix metalloproteinase-2 (MMP-2), MMP-9, vascular endothelial growth factor family and its receptor, KDR, and up-regulated the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 expression by binding with integrin αVβ3, suggesting that angiostatin may play a role in embryo implantation.

Original languageEnglish (US)
Pages (from-to)778-783
Number of pages6
JournalProgress in Biochemistry and Biophysics
Issue number5
StatePublished - Oct 2003


  • Angiostatin
  • Blastocyst
  • Integrin
  • Matrix metalloproteinases (MMPs)
  • TIMPs

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry


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