Abstract
Angiostatin, a 38 ku fragment encompassing the four kringle region of plasminogen, has been identified and characterized to be a potent inhibitor of neovascularization and tumor metastasis. There is a strikingly similarity between tumor metastasis and embryo implantation. However, effect of angiostatin in the mouse blastocyst has never been reported. The results showed for the first time that angiostatin down-regulated the expression of matrix metalloproteinase-2 (MMP-2), MMP-9, vascular endothelial growth factor family and its receptor, KDR, and up-regulated the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 expression by binding with integrin αVβ3, suggesting that angiostatin may play a role in embryo implantation.
Original language | English (US) |
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Pages (from-to) | 778-783 |
Number of pages | 6 |
Journal | Progress in Biochemistry and Biophysics |
Volume | 30 |
Issue number | 5 |
State | Published - Oct 2003 |
Keywords
- Angiostatin
- Blastocyst
- Integrin
- Matrix metalloproteinases (MMPs)
- TIMPs
ASJC Scopus subject areas
- Biophysics
- Biochemistry