Angiostatin, a 38 ku fragment encompassing the four kringle region of plasminogen, has been identified and characterized to be a potent inhibitor of neovascularization and tumor metastasis. There is a strikingly similarity between tumor metastasis and embryo implantation. However, effect of angiostatin in the mouse blastocyst has never been reported. The results showed for the first time that angiostatin down-regulated the expression of matrix metalloproteinase-2 (MMP-2), MMP-9, vascular endothelial growth factor family and its receptor, KDR, and up-regulated the expression of tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 expression by binding with integrin αVβ3, suggesting that angiostatin may play a role in embryo implantation.
|Original language||English (US)|
|Number of pages||6|
|Journal||Progress in Biochemistry and Biophysics|
|State||Published - Oct 2003|
- Matrix metalloproteinases (MMPs)
ASJC Scopus subject areas