Regional myocardial blood flow in man during dipyridamole coronary vasodilation

S. G. Sorensen, B. M. Groves, L. D. Horwitz, T. K. Chaudhuri

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Regional myocardial blood flow before and after intravenous dipyridamole (0.56 mg/kg) was measured during cardiac catheterization in 11 patients using the 133Xe washout technique. Significant increases in heart rate (75 ± 4 vs 87 ± 6, p < 0.004) and decreases in systolic blood pressure (144 ± 8 vs 131 ± 7, p < 0.02) were observed with dipyridamole infusion. However, double product and cardiac output did not differ before or after drug infusion. Regional myocardial blood flow increased from 67 ± 3 (SEM) to 117 ± 3 ml/100 mg/min in myocardial segments supplied by nonobstructed coronary arteries. In stenotic coronary arteries, flow increased from 57 ± 5 to 79 ± 9 ml/100 mg/min with dipyridamole. We conclude that dipyridamole infusion results in flow differences which discriminate stenotic from nonstenotic coronary arteries.

Original languageEnglish (US)
Pages (from-to)735-739
Number of pages5
JournalChest
Volume87
Issue number6
DOIs
StatePublished - 1985

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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