Regional differences in expression of β-tubulin isoforms in schizophrenia

Mark S. Moehle, Richard F. Luduena, Vahram Haroutunian, James H. Meador-Woodruff, Robert E. McCullumsmith

Research output: Contribution to journalArticle

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Abstract

A growing body of evidence suggests that abnormal elements of the cytoskeleton may be associated with the pathophysiology of schizophrenia. Isoforms of a major cytoskeleton protein, β-tubulin, were recently demonstrated to have distinct roles in neuronal differentiation and cell viability. For these reasons, we tested the hypothesis that there are differences in the expression of β-tubulin isoforms (βI-βIV) in the brain in schizophrenia, using western blot analysis in an elderly group of subjects with this illness and a control group. We found that βI-tubulin protein expression was decreased in the anterior cingulate cortex and increased in the dorsolateral prefrontal cortex, but not changed in superior temporal gyrus or hippocampus in schizophrenia. Our data supports the growing body of evidence suggesting abnormalities of the cytoskeleton in schizophrenia.

Original languageEnglish (US)
Pages (from-to)181-186
Number of pages6
JournalSchizophrenia research
Volume135
Issue number1-3
DOIs
StatePublished - Mar 1 2012

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Keywords

  • Anterior cingulate cortex
  • Dorsal lateral prefrontal cortex
  • Postmortem
  • Western blot

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Moehle, M. S., Luduena, R. F., Haroutunian, V., Meador-Woodruff, J. H., & McCullumsmith, R. E. (2012). Regional differences in expression of β-tubulin isoforms in schizophrenia. Schizophrenia research, 135(1-3), 181-186. https://doi.org/10.1016/j.schres.2011.12.010