TY - JOUR
T1 - Regional differences in expression of β-tubulin isoforms in schizophrenia
AU - Moehle, Mark S.
AU - Luduena, Richard F.
AU - Haroutunian, Vahram
AU - Meador-Woodruff, James H.
AU - McCullumsmith, Robert E.
N1 - Funding Information:
This work was supported by the Doris Duke Charitable Foundation Grant # 2009044 (REM), MH53327 (JMW), MH88752 (JMW), MH0740106 (REM), MH094445 (REM), CA54174 (RFL), Department of Defense W81XWH-10-1-0903 (RFL) and SALSI UTHSCSA-UTSA Neuroscience Initiative (RFL). The skilled technical assistance of Veena Prasad is gratefully acknowledged as well as helpful conversations with Dr. Consuelo Walss-Bass.
Copyright:
Copyright 2012 Elsevier B.V., All rights reserved.
PY - 2012/3
Y1 - 2012/3
N2 - A growing body of evidence suggests that abnormal elements of the cytoskeleton may be associated with the pathophysiology of schizophrenia. Isoforms of a major cytoskeleton protein, β-tubulin, were recently demonstrated to have distinct roles in neuronal differentiation and cell viability. For these reasons, we tested the hypothesis that there are differences in the expression of β-tubulin isoforms (βI-βIV) in the brain in schizophrenia, using western blot analysis in an elderly group of subjects with this illness and a control group. We found that βI-tubulin protein expression was decreased in the anterior cingulate cortex and increased in the dorsolateral prefrontal cortex, but not changed in superior temporal gyrus or hippocampus in schizophrenia. Our data supports the growing body of evidence suggesting abnormalities of the cytoskeleton in schizophrenia.
AB - A growing body of evidence suggests that abnormal elements of the cytoskeleton may be associated with the pathophysiology of schizophrenia. Isoforms of a major cytoskeleton protein, β-tubulin, were recently demonstrated to have distinct roles in neuronal differentiation and cell viability. For these reasons, we tested the hypothesis that there are differences in the expression of β-tubulin isoforms (βI-βIV) in the brain in schizophrenia, using western blot analysis in an elderly group of subjects with this illness and a control group. We found that βI-tubulin protein expression was decreased in the anterior cingulate cortex and increased in the dorsolateral prefrontal cortex, but not changed in superior temporal gyrus or hippocampus in schizophrenia. Our data supports the growing body of evidence suggesting abnormalities of the cytoskeleton in schizophrenia.
KW - Anterior cingulate cortex
KW - Dorsal lateral prefrontal cortex
KW - Postmortem
KW - Western blot
UR - http://www.scopus.com/inward/record.url?scp=84857233457&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84857233457&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2011.12.010
DO - 10.1016/j.schres.2011.12.010
M3 - Article
C2 - 22264600
AN - SCOPUS:84857233457
VL - 135
SP - 181
EP - 186
JO - Schizophrenia Research
JF - Schizophrenia Research
SN - 0920-9964
IS - 1-3
ER -