Regeneration of periodontal tissues in non-human primates with rhGDF-5 and beta-tricalcium phosphate

K. B. Emerton, S. J. Drapeau, H. Prasad, M. Rohrer, P. Roffe, K. Hopper, J. Schoolfield, A. Jones, D. L. Cochran

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

The application of growth factors has been advocated in support of periodontal regeneration. Recombinant human growth and differentiation factor-5 (rhGDF-5), a member of the bone morphogenetic protein family, has been used to encourage periodontal tissue regeneration. This study evaluated the dose response of rhGDF-5 lyophilized onto beta-tricalcium phosphate (bTCP) granules for periodontal tissue regeneration in a baboon model. Periodontal defects were created bilaterally in 12 baboons by a split-mouth design. Plaque was allowed to accumulate around wire ligatures to create chronic disease. After 2 mos, the ligatures were removed, and a notch was placed at the base of the defect. Two teeth on each side of the mouth were randomly treated with bTCP only, 0.5, 1.0, or 2.0 mg rhGDF-5/g bTCP. Animals were sacrificed 5 mos post-treatment, with micro-CT and histomorphometric analysis performed. After 5 mos, analysis showed alveolar bone, cementum, and periodontal ligament formation in all treatment groups, with a dose-dependent increase in rhGDF-5-treated groups. Height of periodontal tissues also increased with the addition of rhGDF-5, and the amount of residual graft material decreased with rhGDF-5 treatment. Therefore, rhGDF-5 delivered on bTCP demonstrated effective regeneration of all 3 tissues critical for periodontal repair.

Original languageEnglish (US)
Pages (from-to)1416-1421
Number of pages6
JournalJournal of dental research
Volume90
Issue number12
DOIs
StatePublished - Dec 1 2011

Keywords

  • GDF-5
  • biological factors
  • bone regeneration
  • medical devices
  • periodontal disease
  • periodontal regeneration

ASJC Scopus subject areas

  • Dentistry(all)

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