Abstract
Our aim was to determine whether flow from the submucosal glands of the trachea is reflexly regulated by sensory stimuli from the stomach in the cat, and, if such a gastropulmonary reflex exists, what sensory and motor pathways are important. We found that mechanical stimulation of the gastric mucosa increased submucosal gland secretions from 7.9 ± 0.7 to 17.4 ± 1.7 nl/min (mean ± SE, P < 0.001). This effect was prevented reversibly by cooling both abdominal vagus nerve to -3° C before stimulation and was restored by rewarming the nerves. The effect was prevented irreversibly by cutting both abdominal vagus nerves and was then mimicked by electrically stimulating the central cut end of one of the nerves. This increase in secretions caused by electrical stimulation of the nerve was prevented by administration of atropine sulfate before stimulation. We conclude that stimuli from the stomach reflexly affect the rate of submucosal gland secretion. The sensory limb of this reflex lies in the abdominal vagus nerves, and the motor pathways are mediated by cholinergic muscarinic receptors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1153-1155 |
| Number of pages | 3 |
| Journal | Journal of Applied Physiology Respiratory Environmental and Exercise Physiology |
| Volume | 52 |
| Issue number | 5 |
| State | Published - 1982 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Endocrinology
- Physiology
Cite this
Reflex stimulation of tracheal mucus gland secretion by gastric irritation in cats. / German, V. F.; Corrales, R.; Ueki, I. F.; Nadel, J. A.
In: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, Vol. 52, No. 5, 1982, p. 1153-1155.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Reflex stimulation of tracheal mucus gland secretion by gastric irritation in cats
AU - German, V. F.
AU - Corrales, R.
AU - Ueki, I. F.
AU - Nadel, J. A.
PY - 1982
Y1 - 1982
N2 - Our aim was to determine whether flow from the submucosal glands of the trachea is reflexly regulated by sensory stimuli from the stomach in the cat, and, if such a gastropulmonary reflex exists, what sensory and motor pathways are important. We found that mechanical stimulation of the gastric mucosa increased submucosal gland secretions from 7.9 ± 0.7 to 17.4 ± 1.7 nl/min (mean ± SE, P < 0.001). This effect was prevented reversibly by cooling both abdominal vagus nerve to -3° C before stimulation and was restored by rewarming the nerves. The effect was prevented irreversibly by cutting both abdominal vagus nerves and was then mimicked by electrically stimulating the central cut end of one of the nerves. This increase in secretions caused by electrical stimulation of the nerve was prevented by administration of atropine sulfate before stimulation. We conclude that stimuli from the stomach reflexly affect the rate of submucosal gland secretion. The sensory limb of this reflex lies in the abdominal vagus nerves, and the motor pathways are mediated by cholinergic muscarinic receptors.
AB - Our aim was to determine whether flow from the submucosal glands of the trachea is reflexly regulated by sensory stimuli from the stomach in the cat, and, if such a gastropulmonary reflex exists, what sensory and motor pathways are important. We found that mechanical stimulation of the gastric mucosa increased submucosal gland secretions from 7.9 ± 0.7 to 17.4 ± 1.7 nl/min (mean ± SE, P < 0.001). This effect was prevented reversibly by cooling both abdominal vagus nerve to -3° C before stimulation and was restored by rewarming the nerves. The effect was prevented irreversibly by cutting both abdominal vagus nerves and was then mimicked by electrically stimulating the central cut end of one of the nerves. This increase in secretions caused by electrical stimulation of the nerve was prevented by administration of atropine sulfate before stimulation. We conclude that stimuli from the stomach reflexly affect the rate of submucosal gland secretion. The sensory limb of this reflex lies in the abdominal vagus nerves, and the motor pathways are mediated by cholinergic muscarinic receptors.
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M3 - Article
C2 - 7096138
AN - SCOPUS:0019981302
VL - 52
SP - 1153
EP - 1155
JO - Journal of Applied Physiology
JF - Journal of Applied Physiology
SN - 0161-7567
IS - 5
ER -