Reflex stimulation of tracheal mucus gland secretion by gastric irritation in cats

V. F. German, R. Corrales, I. F. Ueki, J. A. Nadel

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Our aim was to determine whether flow from the submucosal glands of the trachea is reflexly regulated by sensory stimuli from the stomach in the cat, and, if such a gastropulmonary reflex exists, what sensory and motor pathways are important. We found that mechanical stimulation of the gastric mucosa increased submucosal gland secretions from 7.9 ± 0.7 to 17.4 ± 1.7 nl/min (mean ± SE, P < 0.001). This effect was prevented reversibly by cooling both abdominal vagus nerve to -3° C before stimulation and was restored by rewarming the nerves. The effect was prevented irreversibly by cutting both abdominal vagus nerves and was then mimicked by electrically stimulating the central cut end of one of the nerves. This increase in secretions caused by electrical stimulation of the nerve was prevented by administration of atropine sulfate before stimulation. We conclude that stimuli from the stomach reflexly affect the rate of submucosal gland secretion. The sensory limb of this reflex lies in the abdominal vagus nerves, and the motor pathways are mediated by cholinergic muscarinic receptors.

Original languageEnglish (US)
Pages (from-to)1153-1155
Number of pages3
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume52
Issue number5
StatePublished - 1982
Externally publishedYes

Fingerprint

Vagus Nerve
Mucus
Gastric Mucosa
Reflex
Efferent Pathways
Cats
Stomach
Rewarming
Cholinergic Receptors
Muscarinic Receptors
Trachea
Atropine
Electric Stimulation
Extremities

ASJC Scopus subject areas

  • Endocrinology
  • Physiology

Cite this

Reflex stimulation of tracheal mucus gland secretion by gastric irritation in cats. / German, V. F.; Corrales, R.; Ueki, I. F.; Nadel, J. A.

In: Journal of Applied Physiology Respiratory Environmental and Exercise Physiology, Vol. 52, No. 5, 1982, p. 1153-1155.

Research output: Contribution to journalArticle

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