Reduction in pineal N-acetyltransferase activity and pineal and serum melatonin levels in rats after their exposure to red light at night

Jih Hsing Sun; Ken Yaga; Russel J. Reiter; Mario Garza; Lucien C. Manchester; Dun Xian Tan; Burkhard Poeggeler

doi:10.1016/0304-3940(93)90346-M

Reduction in pineal N-acetyltransferase activity and pineal and serum melatonin levels in rats after their exposure to red light at night

Jih Hsing Sun, Ken Yaga, Russel J. Reiter, Mario Garza, Lucien C. Manchester, Dun Xian Tan, Burkhard Poeggeler

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Pineal gland N-acetyltransferase (NAT) activity and pineal and serum levels of melatonin declined linearly in albino rats exposed to different irradiances (low, 170 μW/cm²; moderate, 420 μW/cm²; high, 1040 μW/cm²) red light during the middle of the night. High intensity red light (1040 μW/cm²) was as effective as white light (670 μW/cm²) in suppressing pineal NAT activity and pineal and serum melatonin levels. The lowered melatonin levels and the reduction in NAT activity following exposure to red light suggest that red light cannot be regarded as 'safe' light when studying circadian melatonin production in the albino rat, at least at the intensities used in this experiment.

Original language	English (US)
Pages (from-to)	56-58
Number of pages	3
Journal	Neuroscience Letters
Volume	149
Issue number	1
DOIs	https://doi.org/10.1016/0304-3940(93)90346-M
State	Published - Jan 4 1993

Keywords

Melatonin
N-Acetyltransferase activity
Pineal gland
Red light

ASJC Scopus subject areas

General Neuroscience

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10.1016/0304-3940(93)90346-M

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@article{3a06e2e15a8c482c949858d6f135719e,

title = "Reduction in pineal N-acetyltransferase activity and pineal and serum melatonin levels in rats after their exposure to red light at night",

abstract = "Pineal gland N-acetyltransferase (NAT) activity and pineal and serum levels of melatonin declined linearly in albino rats exposed to different irradiances (low, 170 μW/cm2; moderate, 420 μW/cm2; high, 1040 μW/cm2) red light during the middle of the night. High intensity red light (1040 μW/cm2) was as effective as white light (670 μW/cm2) in suppressing pineal NAT activity and pineal and serum melatonin levels. The lowered melatonin levels and the reduction in NAT activity following exposure to red light suggest that red light cannot be regarded as 'safe' light when studying circadian melatonin production in the albino rat, at least at the intensities used in this experiment.",

keywords = "Melatonin, N-Acetyltransferase activity, Pineal gland, Red light",

author = "Sun, {Jih Hsing} and Ken Yaga and Reiter, {Russel J.} and Mario Garza and Manchester, {Lucien C.} and Tan, {Dun Xian} and Burkhard Poeggeler",

note = "Funding Information: This study was supported by NSF (Grant IBN 9121262).",

year = "1993",

month = jan,

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doi = "10.1016/0304-3940(93)90346-M",

language = "English (US)",

volume = "149",

pages = "56--58",

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T1 - Reduction in pineal N-acetyltransferase activity and pineal and serum melatonin levels in rats after their exposure to red light at night

AU - Sun, Jih Hsing

AU - Yaga, Ken

AU - Reiter, Russel J.

AU - Garza, Mario

AU - Manchester, Lucien C.

AU - Tan, Dun Xian

AU - Poeggeler, Burkhard

N1 - Funding Information: This study was supported by NSF (Grant IBN 9121262).

PY - 1993/1/4

Y1 - 1993/1/4

N2 - Pineal gland N-acetyltransferase (NAT) activity and pineal and serum levels of melatonin declined linearly in albino rats exposed to different irradiances (low, 170 μW/cm2; moderate, 420 μW/cm2; high, 1040 μW/cm2) red light during the middle of the night. High intensity red light (1040 μW/cm2) was as effective as white light (670 μW/cm2) in suppressing pineal NAT activity and pineal and serum melatonin levels. The lowered melatonin levels and the reduction in NAT activity following exposure to red light suggest that red light cannot be regarded as 'safe' light when studying circadian melatonin production in the albino rat, at least at the intensities used in this experiment.

AB - Pineal gland N-acetyltransferase (NAT) activity and pineal and serum levels of melatonin declined linearly in albino rats exposed to different irradiances (low, 170 μW/cm2; moderate, 420 μW/cm2; high, 1040 μW/cm2) red light during the middle of the night. High intensity red light (1040 μW/cm2) was as effective as white light (670 μW/cm2) in suppressing pineal NAT activity and pineal and serum melatonin levels. The lowered melatonin levels and the reduction in NAT activity following exposure to red light suggest that red light cannot be regarded as 'safe' light when studying circadian melatonin production in the albino rat, at least at the intensities used in this experiment.

KW - Melatonin

KW - N-Acetyltransferase activity

KW - Pineal gland

KW - Red light

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DO - 10.1016/0304-3940(93)90346-M

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SN - 0304-3940

VL - 149

SP - 56

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JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 1

ER -

Reduction in pineal N-acetyltransferase activity and pineal and serum melatonin levels in rats after their exposure to red light at night

Abstract

Keywords

ASJC Scopus subject areas

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