Reduction in pineal N-acetyltransferase activity and pineal and serum melatonin levels in rats after their exposure to red light at night

Jih Hsing Sun, Ken Yaga, Russel J. Reiter, Mario Garza, Lucien C. Manchester, Dun Xian Tan, Burkhard Poeggeler

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Pineal gland N-acetyltransferase (NAT) activity and pineal and serum levels of melatonin declined linearly in albino rats exposed to different irradiances (low, 170 μW/cm2; moderate, 420 μW/cm2; high, 1040 μW/cm2) red light during the middle of the night. High intensity red light (1040 μW/cm2) was as effective as white light (670 μW/cm2) in suppressing pineal NAT activity and pineal and serum melatonin levels. The lowered melatonin levels and the reduction in NAT activity following exposure to red light suggest that red light cannot be regarded as 'safe' light when studying circadian melatonin production in the albino rat, at least at the intensities used in this experiment.

Original languageEnglish (US)
Pages (from-to)56-58
Number of pages3
JournalNeuroscience Letters
Volume149
Issue number1
DOIs
StatePublished - Jan 4 1993

Keywords

  • Melatonin
  • N-Acetyltransferase activity
  • Pineal gland
  • Red light

ASJC Scopus subject areas

  • Neuroscience(all)

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