Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 73-76 |
| Number of pages | 4 |
| Journal | Cancer Epidemiology Biomarkers and Prevention |
| Volume | 3 |
| Issue number | 1 |
| State | Published - 1994 |
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ASJC Scopus subject areas
- Epidemiology
- Oncology
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Reduction in oral mucosa micronuclei frequency following alpha-tocopherol treatment of oral leukoplakia. / Benner, Steven E.; Wargovich, Michael J.; Lippman, Scott M.; Fisher, Richard; Velasco, Marco; Winn, Rodger J.; Hong, Waun K.
In: Cancer Epidemiology Biomarkers and Prevention, Vol. 3, No. 1, 1994, p. 73-76.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Reduction in oral mucosa micronuclei frequency following alpha-tocopherol treatment of oral leukoplakia
AU - Benner, Steven E.
AU - Wargovich, Michael J.
AU - Lippman, Scott M.
AU - Fisher, Richard
AU - Velasco, Marco
AU - Winn, Rodger J.
AU - Hong, Waun K.
PY - 1994
Y1 - 1994
N2 - Micronuclei frequency, a marker of genotoxicity, was studied within a trial of α-tocopherol for chemoprevention of oral leukoplakia. Oral swabs were obtained from two sites, the leukoplakia lesion and normal-appearing mucosa, at baseline and following 24 weeks of therapy with 400 international units of α-tocopherol twice daily. These specimens were analyzed for micronuclei frequency. The major risk factors for oral carcinogenesis in the group studied were cigarette smoking and alcohol consumption. α-tocopherol therapy produced a significant reduction in micronuclei frequencies in specimens from both the visible lesions (P < 0.01) and the normal-appearing mucosa (P < 0.01). The micronuclei frequencies, both at baseline and following therapy, were greater in specimens taken from the lesion than in those from the normal-appearing mucosa. Although these results indicate that α-tocopherol has a beneficial effect in oral carcinogenesis, there was no significant clinical or histological response associated with the change in micronuclei frequency. Micronuclei frequency has not yet been validated as a biomarker for cancer incidence, and consequently, its utility as an intermediate end point for chemoprevention trials is not known. Determining clinical significance of micronuclei frequency patterns in oral carcinogenesis and chemoprevention will require further study.
AB - Micronuclei frequency, a marker of genotoxicity, was studied within a trial of α-tocopherol for chemoprevention of oral leukoplakia. Oral swabs were obtained from two sites, the leukoplakia lesion and normal-appearing mucosa, at baseline and following 24 weeks of therapy with 400 international units of α-tocopherol twice daily. These specimens were analyzed for micronuclei frequency. The major risk factors for oral carcinogenesis in the group studied were cigarette smoking and alcohol consumption. α-tocopherol therapy produced a significant reduction in micronuclei frequencies in specimens from both the visible lesions (P < 0.01) and the normal-appearing mucosa (P < 0.01). The micronuclei frequencies, both at baseline and following therapy, were greater in specimens taken from the lesion than in those from the normal-appearing mucosa. Although these results indicate that α-tocopherol has a beneficial effect in oral carcinogenesis, there was no significant clinical or histological response associated with the change in micronuclei frequency. Micronuclei frequency has not yet been validated as a biomarker for cancer incidence, and consequently, its utility as an intermediate end point for chemoprevention trials is not known. Determining clinical significance of micronuclei frequency patterns in oral carcinogenesis and chemoprevention will require further study.
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M3 - Article
C2 - 8118389
AN - SCOPUS:0028302387
VL - 3
SP - 73
EP - 76
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
SN - 1055-9965
IS - 1
ER -