Reduction in oral mucosa micronuclei frequency following alpha-tocopherol treatment of oral leukoplakia

Steven E. Benner, Michael J. Wargovich, Scott M. Lippman, Richard Fisher, Marco Velasco, Rodger J. Winn, Waun K. Hong

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Original languageEnglish
Pages (from-to)73-76
Number of pages4
JournalCancer Epidemiology Biomarkers and Prevention
Volume3
Issue number1
StatePublished - 1994

Fingerprint

Oral Leukoplakia
Tocopherols
Mouth Mucosa
alpha-Tocopherol
Chemoprevention
Carcinogenesis
Mucous Membrane
Leukoplakia
Therapeutics
Tumor Biomarkers
Alcohol Drinking
Smoking
Incidence

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Reduction in oral mucosa micronuclei frequency following alpha-tocopherol treatment of oral leukoplakia. / Benner, Steven E.; Wargovich, Michael J.; Lippman, Scott M.; Fisher, Richard; Velasco, Marco; Winn, Rodger J.; Hong, Waun K.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 3, No. 1, 1994, p. 73-76.

Research output: Contribution to journalArticle

Benner, Steven E. ; Wargovich, Michael J. ; Lippman, Scott M. ; Fisher, Richard ; Velasco, Marco ; Winn, Rodger J. ; Hong, Waun K. / Reduction in oral mucosa micronuclei frequency following alpha-tocopherol treatment of oral leukoplakia. In: Cancer Epidemiology Biomarkers and Prevention. 1994 ; Vol. 3, No. 1. pp. 73-76.
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abstract = "Micronuclei frequency, a marker of genotoxicity, was studied within a trial of α-tocopherol for chemoprevention of oral leukoplakia. Oral swabs were obtained from two sites, the leukoplakia lesion and normal-appearing mucosa, at baseline and following 24 weeks of therapy with 400 international units of α-tocopherol twice daily. These specimens were analyzed for micronuclei frequency. The major risk factors for oral carcinogenesis in the group studied were cigarette smoking and alcohol consumption. α-tocopherol therapy produced a significant reduction in micronuclei frequencies in specimens from both the visible lesions (P < 0.01) and the normal-appearing mucosa (P < 0.01). The micronuclei frequencies, both at baseline and following therapy, were greater in specimens taken from the lesion than in those from the normal-appearing mucosa. Although these results indicate that α-tocopherol has a beneficial effect in oral carcinogenesis, there was no significant clinical or histological response associated with the change in micronuclei frequency. Micronuclei frequency has not yet been validated as a biomarker for cancer incidence, and consequently, its utility as an intermediate end point for chemoprevention trials is not known. Determining clinical significance of micronuclei frequency patterns in oral carcinogenesis and chemoprevention will require further study.",
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T1 - Reduction in oral mucosa micronuclei frequency following alpha-tocopherol treatment of oral leukoplakia

AU - Benner, Steven E.

AU - Wargovich, Michael J.

AU - Lippman, Scott M.

AU - Fisher, Richard

AU - Velasco, Marco

AU - Winn, Rodger J.

AU - Hong, Waun K.

PY - 1994

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N2 - Micronuclei frequency, a marker of genotoxicity, was studied within a trial of α-tocopherol for chemoprevention of oral leukoplakia. Oral swabs were obtained from two sites, the leukoplakia lesion and normal-appearing mucosa, at baseline and following 24 weeks of therapy with 400 international units of α-tocopherol twice daily. These specimens were analyzed for micronuclei frequency. The major risk factors for oral carcinogenesis in the group studied were cigarette smoking and alcohol consumption. α-tocopherol therapy produced a significant reduction in micronuclei frequencies in specimens from both the visible lesions (P < 0.01) and the normal-appearing mucosa (P < 0.01). The micronuclei frequencies, both at baseline and following therapy, were greater in specimens taken from the lesion than in those from the normal-appearing mucosa. Although these results indicate that α-tocopherol has a beneficial effect in oral carcinogenesis, there was no significant clinical or histological response associated with the change in micronuclei frequency. Micronuclei frequency has not yet been validated as a biomarker for cancer incidence, and consequently, its utility as an intermediate end point for chemoprevention trials is not known. Determining clinical significance of micronuclei frequency patterns in oral carcinogenesis and chemoprevention will require further study.

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