Reduced vascular sensitivity to norepinephrine in portal-hypertensive rats

J. W. Kiel, V. Pitts, J. N. Benoit

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

The development of portal hypertension following chronic portal vein stenosis is accompanied by a significant increase in intestinal blood flow. The present study was designed to determine whether intestinal vascular sensitivity to norepinephrine (NE) is also affected by chronic portal vein stenosis. Using a blood-prefused, in situ rat small intestine preparation, we found that, when compared with control animals, a significantly greater molar concentration of NE was required to achieve the same proportional increase in intestinal vascular resistance in portal-hypertensive animals. The mean ED50 value (±SE) for the portal-hypertensive group (704.3 ± 186.1 nM) was significantly greater (P <0.05) than the mean ED50 value for the control group (271.4+48.1 nM). This finding implies that sympathetic maintenance of intestinal vascular tone may be impaired following chronic portal vein stenosis, possibly accounting for part of the intestinal hyperemia associated with portal hypertension.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Gastrointestinal and Liver Physiology
Volume11
Issue number2
StatePublished - 1985

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Portal Vein
Blood Vessels
Norepinephrine
Pathologic Constriction
Portal Hypertension
Hyperemia
Vascular Resistance
Small Intestine
Maintenance
Control Groups

ASJC Scopus subject areas

  • Physiology
  • Gastroenterology

Cite this

Reduced vascular sensitivity to norepinephrine in portal-hypertensive rats. / Kiel, J. W.; Pitts, V.; Benoit, J. N.

In: American Journal of Physiology - Gastrointestinal and Liver Physiology, Vol. 11, No. 2, 1985.

Research output: Contribution to journalArticle

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