Reduced serum tricyclic levels due to gel separators

Alan B. Levy, Martha Walters, Stephen L. Stern

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Sixty-three blood samples were obtained from 48 subjects taking tricyclic antidepressants. Samples were simultaneously collected in Becton-Dickinson Vacutainer tubes for measurement of serum and plasma tricyclic antidepressant concentrations. Serum was drawn into red stopper tubes (without gel separator) and into speckled stopper serum separator tubes (with gel separator), while plasma was collected in green stopper tubes (heparinized). Imipramine, desipramine, amitriptyline, and nortriptyline concentrations were all significantly lower in serum separator samples than in either plasma or red stopper serum collection tubes. Serum and plasma concentrations were similar.

Original languageEnglish (US)
Pages (from-to)423-424
Number of pages2
JournalJournal of Clinical Psychopharmacology
Issue number6
StatePublished - Dec 1987

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)


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