Reduced leucine-enkephalin-like immunoreactive substance in hamster basal ganglia after long-term ethanol exposure

Kenneth Blum, Arthur H. Briggs, Steven F.A. Elston, Leonard Delallo, Peter J. Sheridan, Madhabananda Sar

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Golden Syrian hamsters were placed individually in cages with three drinking bottles-one empty, one containing water, and the third containing water and ethanol. Control hamsters received water only. After 1 year the experimental hamsters showed a significantly lower concentration of leucine-enkephalin-like immunoreactive substance in the basal ganglia than the control hamsters. This finding indicates that the action of ethanol involves endogenous peptidyl opiates.

Original languageEnglish (US)
Pages (from-to)1425-1427
Number of pages3
JournalScience
Volume216
Issue number4553
DOIs
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • General

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