Reduced induction of drug metabolism in the elderly

S. A.M. Salem, P. Rajjayabun, A. M.M. Shepherd, I. H. Stevenson

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


Young and elderly subjects were given the hypnotic dichloralphenazone (Welldorm) in a dose of 20 mg/kg nightly for two weeks and the extent of induction of liver microsomal drug metabolism was assessed from alteration in the plasma elimination of quinine and antipyrine (phenazone). With both indices, there was a significant increase in plasma drug clearance in young subjects following dichloralphenazone treatment but no significant alterations occured in the elderly group. These results indicate that, in addition to being less able to metabolize some drugs, elderly patients show a reduced induction response. They may therefore be less likely to become tolerant to those drugs which are inactivated by metabolism.

Original languageEnglish (US)
Pages (from-to)68-73
Number of pages6
JournalAge and ageing
Issue number2
StatePublished - May 1978
Externally publishedYes

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology


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