Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice

Yuji Ikeno, Gene B. Hubbard, Shuko Lee, Lisa A. Cortez, Christie M. Lew, Celeste R. Webb, Darlene E. Berryman, Edward O. List, John J. Kopchick, Andrzej Bartke

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

Although studies of Ames and Snell dwarf mice have suggested possible important roles of the growth hormone (GH)/ insulin-like growth factor-1 (IGF-1) axis in aging and age-related diseases, the results cannot rule out the possibility of other hormonal changes playing an important role in the life extension exhibited by these dwarf mice. Therefore, growth hormone receptor/binding protein (GHR/BP) knockout (KO) mice would be valuable animals to directly assess the roles of somatotropic axis in aging and age-related diseases because the primary hormonal change is due to GH/IGF-1 defi-ciency. Our pathological findings showed GHR/BP KO mice to have a lower incidence and delayed occurrence of fatal neoplastic lesions compared with their wild-type littermates. These changes of fatal neoplasms are similar to the effects observed with calorie restriction and therefore could possibly be a major contributing factor to the extended life span observed in the GHR/BP KO mice.

Original languageEnglish (US)
Pages (from-to)522-529
Number of pages8
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume64
Issue number5
DOIs
StatePublished - May 2009

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Somatotropin Receptors
Knockout Mice
Somatomedins
Growth Hormone
Incidence
Life Expectancy
somatotropin-binding protein
Neoplasms

Keywords

  • Aging
  • Growth hormone receptor/binding protein
  • Knockout mouse
  • Neoplastic disease

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology
  • Medicine(all)

Cite this

Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. / Ikeno, Yuji; Hubbard, Gene B.; Lee, Shuko; Cortez, Lisa A.; Lew, Christie M.; Webb, Celeste R.; Berryman, Darlene E.; List, Edward O.; Kopchick, John J.; Bartke, Andrzej.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 64, No. 5, 05.2009, p. 522-529.

Research output: Contribution to journalArticle

Ikeno, Yuji ; Hubbard, Gene B. ; Lee, Shuko ; Cortez, Lisa A. ; Lew, Christie M. ; Webb, Celeste R. ; Berryman, Darlene E. ; List, Edward O. ; Kopchick, John J. ; Bartke, Andrzej. / Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2009 ; Vol. 64, No. 5. pp. 522-529.
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