Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice

Yuji Ikeno; Gene B. Hubbard; Shuko Lee; Lisa A. Cortez; Christie M. Lew; Celeste R. Webb; Darlene E. Berryman; Edward O. List; John J. Kopchick; Andrzej Bartke

doi:10.1093/gerona/glp017

Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice

Yuji Ikeno, Gene B. Hubbard, Shuko Lee, Lisa A. Cortez, Christie M. Lew, Celeste R. Webb, Darlene E. Berryman, Edward O. List, John J. Kopchick, Andrzej Bartke

Research output: Contribution to journal › Article › peer-review

204 Scopus citations

Abstract

Although studies of Ames and Snell dwarf mice have suggested possible important roles of the growth hormone (GH)/ insulin-like growth factor-1 (IGF-1) axis in aging and age-related diseases, the results cannot rule out the possibility of other hormonal changes playing an important role in the life extension exhibited by these dwarf mice. Therefore, growth hormone receptor/binding protein (GHR/BP) knockout (KO) mice would be valuable animals to directly assess the roles of somatotropic axis in aging and age-related diseases because the primary hormonal change is due to GH/IGF-1 defi-ciency. Our pathological findings showed GHR/BP KO mice to have a lower incidence and delayed occurrence of fatal neoplastic lesions compared with their wild-type littermates. These changes of fatal neoplasms are similar to the effects observed with calorie restriction and therefore could possibly be a major contributing factor to the extended life span observed in the GHR/BP KO mice.

Original language	English (US)
Pages (from-to)	522-529
Number of pages	8
Journal	Journals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume	64
Issue number	5
DOIs	https://doi.org/10.1093/gerona/glp017
State	Published - May 2009

Keywords

Aging
Growth hormone receptor/binding protein
Knockout mouse
Neoplastic disease

ASJC Scopus subject areas

General Medicine

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Ikeno, Y., Hubbard, G. B., Lee, S., Cortez, L. A., Lew, C. M., Webb, C. R., Berryman, D. E., List, E. O., Kopchick, J. J., & Bartke, A. (2009). Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 64(5), 522-529. https://doi.org/10.1093/gerona/glp017

Ikeno, Y, Hubbard, GB, Lee, S, Cortez, LA, Lew, CM, Webb, CR, Berryman, DE, List, EO, Kopchick, JJ & Bartke, A 2009, 'Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 64, no. 5, pp. 522-529. https://doi.org/10.1093/gerona/glp017

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title = "Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice",

abstract = "Although studies of Ames and Snell dwarf mice have suggested possible important roles of the growth hormone (GH)/ insulin-like growth factor-1 (IGF-1) axis in aging and age-related diseases, the results cannot rule out the possibility of other hormonal changes playing an important role in the life extension exhibited by these dwarf mice. Therefore, growth hormone receptor/binding protein (GHR/BP) knockout (KO) mice would be valuable animals to directly assess the roles of somatotropic axis in aging and age-related diseases because the primary hormonal change is due to GH/IGF-1 defi-ciency. Our pathological findings showed GHR/BP KO mice to have a lower incidence and delayed occurrence of fatal neoplastic lesions compared with their wild-type littermates. These changes of fatal neoplasms are similar to the effects observed with calorie restriction and therefore could possibly be a major contributing factor to the extended life span observed in the GHR/BP KO mice.",

keywords = "Aging, Growth hormone receptor/binding protein, Knockout mouse, Neoplastic disease",

author = "Yuji Ikeno and Hubbard, {Gene B.} and Shuko Lee and Cortez, {Lisa A.} and Lew, {Christie M.} and Webb, {Celeste R.} and Berryman, {Darlene E.} and List, {Edward O.} and Kopchick, {John J.} and Andrzej Bartke",

note = "Funding Information: This research was supported by National Institutes of Health grants AG13319 (Y.I.), AG19899 (A.B. and J.J.K.), CA099904-01 (J.J.K.), U24 DK059630 (J.J.K.), and DK064905 (D.E.B.); AICR grant ( 01A069 ) (Y.I.); VA Merit Review Grant (Y.I.) from Veteran Affairs ; grant from Glenn Foundation for Medical Research (Y.I.); the American Federation for Aging Research grant (Y.I.); The Ellison Medical Foundation grant (A.B.); Eminent Scholar Program (J.J.K.) from the State of Ohio ; and the Diabetes Research Initiative grant (D.E.B. and J.J.K.) from Ohio University.",

year = "2009",

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doi = "10.1093/gerona/glp017",

language = "English (US)",

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AU - Ikeno, Yuji

AU - Hubbard, Gene B.

AU - Lee, Shuko

AU - Cortez, Lisa A.

AU - Lew, Christie M.

AU - Webb, Celeste R.

AU - Berryman, Darlene E.

AU - List, Edward O.

AU - Kopchick, John J.

AU - Bartke, Andrzej

N1 - Funding Information: This research was supported by National Institutes of Health grants AG13319 (Y.I.), AG19899 (A.B. and J.J.K.), CA099904-01 (J.J.K.), U24 DK059630 (J.J.K.), and DK064905 (D.E.B.); AICR grant ( 01A069 ) (Y.I.); VA Merit Review Grant (Y.I.) from Veteran Affairs ; grant from Glenn Foundation for Medical Research (Y.I.); the American Federation for Aging Research grant (Y.I.); The Ellison Medical Foundation grant (A.B.); Eminent Scholar Program (J.J.K.) from the State of Ohio ; and the Diabetes Research Initiative grant (D.E.B. and J.J.K.) from Ohio University.

PY - 2009/5

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N2 - Although studies of Ames and Snell dwarf mice have suggested possible important roles of the growth hormone (GH)/ insulin-like growth factor-1 (IGF-1) axis in aging and age-related diseases, the results cannot rule out the possibility of other hormonal changes playing an important role in the life extension exhibited by these dwarf mice. Therefore, growth hormone receptor/binding protein (GHR/BP) knockout (KO) mice would be valuable animals to directly assess the roles of somatotropic axis in aging and age-related diseases because the primary hormonal change is due to GH/IGF-1 defi-ciency. Our pathological findings showed GHR/BP KO mice to have a lower incidence and delayed occurrence of fatal neoplastic lesions compared with their wild-type littermates. These changes of fatal neoplasms are similar to the effects observed with calorie restriction and therefore could possibly be a major contributing factor to the extended life span observed in the GHR/BP KO mice.

AB - Although studies of Ames and Snell dwarf mice have suggested possible important roles of the growth hormone (GH)/ insulin-like growth factor-1 (IGF-1) axis in aging and age-related diseases, the results cannot rule out the possibility of other hormonal changes playing an important role in the life extension exhibited by these dwarf mice. Therefore, growth hormone receptor/binding protein (GHR/BP) knockout (KO) mice would be valuable animals to directly assess the roles of somatotropic axis in aging and age-related diseases because the primary hormonal change is due to GH/IGF-1 defi-ciency. Our pathological findings showed GHR/BP KO mice to have a lower incidence and delayed occurrence of fatal neoplastic lesions compared with their wild-type littermates. These changes of fatal neoplasms are similar to the effects observed with calorie restriction and therefore could possibly be a major contributing factor to the extended life span observed in the GHR/BP KO mice.

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KW - Neoplastic disease

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Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice

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