Reduced Efficacy of Low-dose Topical Steroids in Dry Eye Disease Associated With Graft-versus-Host Disease

Jia Yin, Ahmad Kheirkhah, Thomas Dohlman, Ujwala Saboo, Reza Dana

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Purpose: To compare the response of dry eye disease (DED) to treatment with topical steroid in patients with and without graft-vs-host disease (GVHD). Design: Post hoc analysis of a double-masked, randomized clinical trial. Methods: This single-center study included 42 patients with moderate-to-severe DED associated with (n = 21) or without (n = 21) chronic GVHD. In each group, patients received either loteprednol etabonate 0.5% ophthalmic suspension or artificial tears twice daily for 4 weeks. Clinical data, including Ocular Surface Disease Index (OSDI) questionnaire, corneal fluorescein staining (CFS), conjunctival lissamine green staining, tear break-up time (TBUT), and Schirmer test, were evaluated before and after treatment. Results: There were no significant differences in signs and symptoms of DED between the groups at baseline. In non-GVHD patients receiving loteprednol treatment, the average OSDI score decreased by 34% from 49.5 ± 5.9 to 32.6 ± 4.8 (mean ± standard error of the mean, P =.001) and the average CFS score decreased by 41% from 5.6 ± 0.6 to 3.3 ± 0.9 (P =.02). On the other hand, loteprednol treatment in GVHD patients resulted in minimal change in OSDI (59.2 ± 6.7 to 61.1 ± 7.1, 3% increase, P =.66) and CFS (5.5 ± 0.5 to 5.3 ± 1.1, 4% decrease, P =.85) scores. Treatment with artificial tears resulted in 22% decrease of OSDI (P =.10) and 32% decrease of CFS (P =.02) scores in non-GVHD patients, and had minimal effect in patients with GVHD. Conclusions: DED patients with ocular GVHD have a less favorable response to a low-dose topical steroid regimen compared with those without ocular GVHD even with similar baseline disease severity.

Original languageEnglish (US)
Pages (from-to)17-23
Number of pages7
JournalAmerican Journal of Ophthalmology
Volume190
DOIs
StatePublished - Jun 2018
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology

Fingerprint Dive into the research topics of 'Reduced Efficacy of Low-dose Topical Steroids in Dry Eye Disease Associated With Graft-versus-Host Disease'. Together they form a unique fingerprint.

Cite this