Reduced DHA transfer in diabetic pregnancies: Mechanistic basis and long-term neurodevelopmental implications

Michelle P. Judge, Sharon G. Casavant, Juliana A.M. Dias, Jacqueline M. McGrath

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Infants born to diabetic mothers have a higher frequency of impaired neurodevelopment. The omega-3 or n-3 fatty acid docosahexaenoic acid (DHA) is an important structural component of neural tissue and is critical for fetal brain development. Maternal DHA supplementation during pregnancy is linked to better infant neurodevelopment; however, maternal-fetal transfer of DHA is reduced in women with diabetes. Evidence of mechanisms explaining altered maternal-fetal DHA transfer in this population is limited. This review explores existing evidence underpinning reduced maternal-fetal DHA transfer in maternal fuel metabolism in this population. Further research is necessary to evaluate the role of peroxisome proliferatoractivated receptors in modulating placental fatty acid binding and maternal-fetal DHA transfer. Considerations for clinical practice include a diet high in DHA and/or provision of supplemental DHA to obstetric diabetic patients within minimum guidelines.

Original languageEnglish (US)
Pages (from-to)411-420
Number of pages10
JournalNutrition Reviews
Volume74
Issue number6
DOIs
StatePublished - Jun 2016
Externally publishedYes

Keywords

  • Altered omega-3 transfer
  • Diabetes
  • Infant developmental outcomes
  • Omega-3 fatty acids
  • PPAR
  • Pregestational type 2 diabetes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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