Reduced concentrations of N-acetylaspartate (NAA) and the NAA-creatine ratio in the basal ganglia in bipolar disorder: A study using 3-Tesla proton magnetic resonance spectroscopy

Mark A. Frye; M. Albert Thomas; Kenneth Yue; Nader Binesh; Pablo Davanzo; Joseph Ventura; Joseph O'Neill; Barry Guze; John G. Curran; Jim Mintz

doi:10.1016/j.pscychresns.2006.11.003

Reduced concentrations of N-acetylaspartate (NAA) and the NAA-creatine ratio in the basal ganglia in bipolar disorder: A study using 3-Tesla proton magnetic resonance spectroscopy

Mark A. Frye, M. Albert Thomas, Kenneth Yue, Nader Binesh, Pablo Davanzo, Joseph Ventura, Joseph O'Neill, Barry Guze, John G. Curran, Jim Mintz

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

The N-acetylaspartate (NAA) peak is prominent in the proton magnetic resonance spectrum and is thought to reflect neuron loss or dysfunction. This study was conducted to explore NAA biochemistry and its clinical correlates in mania. Subjects comprised 16 manic patients and 17 controls who underwent a structured diagnostic interview and ¹H magnetic resonance spectroscopy (MRS) acquisition. STEAM ¹H MRS (TR/TE/TM = 2000/20/8 ms) was acquired at 3 Tesla from 2 × 2 × 2 cm³ voxels in anterior cingulate (AC), right basal ganglia (BG), and left occipital-parietal white matter (OP). Absolute metabolite concentrations and ratios to creatine were calculated using the LC Model. The mean absolute concentrations of NAA and NAA-creatine ratio in the BG were significantly lower in manic subjects than in controls. There was a significant inverse correlation between NAA in the BG and the number of prior hospitalizations for mania. These data suggest BG pathology in mania and that NAA decrements may mark prior manic episode burden. Limitations of this study include small sample size and lack of tissue segmentation. Further study is encouraged to clarify state vs. trait aspects of NAA in bipolar disorder.

Original language	English (US)
Pages (from-to)	259-265
Number of pages	7
Journal	Psychiatry Research - Neuroimaging
Volume	154
Issue number	3
DOIs	https://doi.org/10.1016/j.pscychresns.2006.11.003
State	Published - Apr 15 2007
Externally published	Yes

Keywords

Basal ganglia
Magnetic
Mania
N-acetylaspartate
Resonance
Spectroscopy

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

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10.1016/j.pscychresns.2006.11.003

Cite this

Frye, M. A., Thomas, M. A., Yue, K., Binesh, N., Davanzo, P., Ventura, J., O'Neill, J., Guze, B., Curran, J. G., & Mintz, J. (2007). Reduced concentrations of N-acetylaspartate (NAA) and the NAA-creatine ratio in the basal ganglia in bipolar disorder: A study using 3-Tesla proton magnetic resonance spectroscopy. Psychiatry Research - Neuroimaging, 154(3), 259-265. https://doi.org/10.1016/j.pscychresns.2006.11.003

Reduced concentrations of N-acetylaspartate (NAA) and the NAA-creatine ratio in the basal ganglia in bipolar disorder : A study using 3-Tesla proton magnetic resonance spectroscopy. / Frye, Mark A.; Thomas, M. Albert; Yue, Kenneth et al.

In: Psychiatry Research - Neuroimaging, Vol. 154, No. 3, 15.04.2007, p. 259-265.

Research output: Contribution to journal › Article › peer-review

Frye, MA, Thomas, MA, Yue, K, Binesh, N, Davanzo, P, Ventura, J, O'Neill, J, Guze, B, Curran, JG & Mintz, J 2007, 'Reduced concentrations of N-acetylaspartate (NAA) and the NAA-creatine ratio in the basal ganglia in bipolar disorder: A study using 3-Tesla proton magnetic resonance spectroscopy', Psychiatry Research - Neuroimaging, vol. 154, no. 3, pp. 259-265. https://doi.org/10.1016/j.pscychresns.2006.11.003

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title = "Reduced concentrations of N-acetylaspartate (NAA) and the NAA-creatine ratio in the basal ganglia in bipolar disorder: A study using 3-Tesla proton magnetic resonance spectroscopy",

abstract = "The N-acetylaspartate (NAA) peak is prominent in the proton magnetic resonance spectrum and is thought to reflect neuron loss or dysfunction. This study was conducted to explore NAA biochemistry and its clinical correlates in mania. Subjects comprised 16 manic patients and 17 controls who underwent a structured diagnostic interview and 1H magnetic resonance spectroscopy (MRS) acquisition. STEAM 1H MRS (TR/TE/TM = 2000/20/8 ms) was acquired at 3 Tesla from 2 × 2 × 2 cm3 voxels in anterior cingulate (AC), right basal ganglia (BG), and left occipital-parietal white matter (OP). Absolute metabolite concentrations and ratios to creatine were calculated using the LC Model. The mean absolute concentrations of NAA and NAA-creatine ratio in the BG were significantly lower in manic subjects than in controls. There was a significant inverse correlation between NAA in the BG and the number of prior hospitalizations for mania. These data suggest BG pathology in mania and that NAA decrements may mark prior manic episode burden. Limitations of this study include small sample size and lack of tissue segmentation. Further study is encouraged to clarify state vs. trait aspects of NAA in bipolar disorder.",

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note = "Funding Information: This work was supported by grants from the Theodore and Vada Stanley Foundation and NIH grant MH58284 (PI: M. Albert Thomas). The scientific support of Ms. Susan Masseling and Mr. Art Ambrosio is gratefully acknowledged.",

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AU - Thomas, M. Albert

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AU - O'Neill, Joseph

AU - Guze, Barry

AU - Curran, John G.

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Reduced concentrations of N-acetylaspartate (NAA) and the NAA-creatine ratio in the basal ganglia in bipolar disorder: A study using 3-Tesla proton magnetic resonance spectroscopy

Abstract

Keywords

ASJC Scopus subject areas

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