TY - JOUR
T1 - Red blood cell fatty acid patterns from 7 countries
T2 - Focus on the Omega-3 index
AU - Schuchardt, Jan Philipp
AU - Cerrato, Marianna
AU - Ceseri, Martina
AU - DeFina, Laura F.
AU - Delgado, Graciela E.
AU - Gellert, Sandra
AU - Hahn, Andreas
AU - Howard, Barbara V.
AU - Kadota, Aya
AU - Kleber, Marcus E.
AU - Latini, Roberto
AU - Maerz, Winfried
AU - Manson, Jo Ann E.
AU - Mora, Samia
AU - Park, Yongsoon
AU - Sala-Vila, Aleix
AU - von Schacky, Clemens
AU - Sekikawa, Akira
AU - Tintle, Nathan
AU - Tucker, Katherine L.
AU - Vasan, Ramachandran S.
AU - Harris, William S.
N1 - Publisher Copyright:
© 2022
PY - 2022/4
Y1 - 2022/4
N2 - Red blood cell (RBC) fatty acid (FA) patterns are becoming recognized as long-term biomarkers of tissue FA composition, but different analytical methods have complicated inter-study and international comparisons. Here we report RBC FA data, with a focus on the Omega-3 Index (EPA + DHA in% of total FAs in RBC), from samples of seven countries (USA, Canada, Italy, Spain, Germany, South Korea, and Japan) including 167,347 individuals (93% of all samples were from the US). FA data were generated by a uniform methodology from a variety of interventional and observational studies and from clinical laboratories. The cohorts differed in size, demographics, health status, and year of collection. Only the Canadian cohort was a formal, representative population-based survey. The mean Omega-3 Index of each country was categorized as desirable (>8%), moderate (>6% to 8%), low (>4% to 6%), or very low (≤4%). Only cohorts from Alaska (treated separately from the US), South Korea and Japan showed a desirable Omega-3 Index. The Spanish cohort had a moderate Omega-3 Index, while cohorts from the US, Canada, Italy, and Germany were all classified as low. This study is limited by the use of cohorts of convenience and small sample sizes in some countries. Countries undertaking national health status studies should utilize a uniform method to measure Omega-3 FA levels.
AB - Red blood cell (RBC) fatty acid (FA) patterns are becoming recognized as long-term biomarkers of tissue FA composition, but different analytical methods have complicated inter-study and international comparisons. Here we report RBC FA data, with a focus on the Omega-3 Index (EPA + DHA in% of total FAs in RBC), from samples of seven countries (USA, Canada, Italy, Spain, Germany, South Korea, and Japan) including 167,347 individuals (93% of all samples were from the US). FA data were generated by a uniform methodology from a variety of interventional and observational studies and from clinical laboratories. The cohorts differed in size, demographics, health status, and year of collection. Only the Canadian cohort was a formal, representative population-based survey. The mean Omega-3 Index of each country was categorized as desirable (>8%), moderate (>6% to 8%), low (>4% to 6%), or very low (≤4%). Only cohorts from Alaska (treated separately from the US), South Korea and Japan showed a desirable Omega-3 Index. The Spanish cohort had a moderate Omega-3 Index, while cohorts from the US, Canada, Italy, and Germany were all classified as low. This study is limited by the use of cohorts of convenience and small sample sizes in some countries. Countries undertaking national health status studies should utilize a uniform method to measure Omega-3 FA levels.
KW - DHA
KW - EPA
KW - Erythrocyte
KW - Fatty acid
KW - Fish intake
KW - Omega-3 Index
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U2 - 10.1016/j.plefa.2022.102418
DO - 10.1016/j.plefa.2022.102418
M3 - Article
C2 - 35366625
AN - SCOPUS:85127119172
SN - 0952-3278
VL - 179
JO - Prostaglandins Leukotrienes and Essential Fatty Acids
JF - Prostaglandins Leukotrienes and Essential Fatty Acids
M1 - 102418
ER -