Red Blood Cell Deformability in Human and Experimental Sepsis

Thelma C. Hurd; Kumar S. Dasmahapatra; Benjamin F. Rush; George W. Machiedo

doi:10.1001/archsurg.1988.01400260101012

Red Blood Cell Deformability in Human and Experimental Sepsis

Thelma C. Hurd, Kumar S. Dasmahapatra, Benjamin F. Rush, George W. Machiedo

Department of Surgery

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

Red blood cell (RBC) “deformability” is necessary for maintenance of normal microcirculation. To determine whether RBC deformability was affected in human or murine sepsis, a deformability index was determined in a human study and a murine model. Deformability was decreased postoperatively in patients with sepsis (0.49 ±0.12) compared with patients without sepsis (1.62±0.13) and normal control volunteers (1.51 ±0.17). Deformability was decreased in rats that had undergone cecal ligation and puncture (0.37±0.06) compared with that of sham-operated rats (0.76 ±0.12), as well as in endotoxemic rats (0.38 ±0.4) compared with control rats (0.82 ±0.11). These data suggest that RBC deformability decreases in both human and murine sepsis. This effect could be an important factor in the disordered oxygen utilization noted in human sepsis, and its correction could lead to better tissue oxygenation and preserved organ function.

Original language	English (US)
Pages (from-to)	217-220
Number of pages	4
Journal	Archives of Surgery
Volume	123
Issue number	2
DOIs	https://doi.org/10.1001/archsurg.1988.01400260101012
State	Published - Feb 1988

ASJC Scopus subject areas

Surgery

Access to Document

10.1001/archsurg.1988.01400260101012

Cite this

@article{a277a23f33ee4248b193ca89007ebafa,

title = "Red Blood Cell Deformability in Human and Experimental Sepsis",

abstract = "Red blood cell (RBC) “deformability” is necessary for maintenance of normal microcirculation. To determine whether RBC deformability was affected in human or murine sepsis, a deformability index was determined in a human study and a murine model. Deformability was decreased postoperatively in patients with sepsis (0.49 ±0.12) compared with patients without sepsis (1.62±0.13) and normal control volunteers (1.51 ±0.17). Deformability was decreased in rats that had undergone cecal ligation and puncture (0.37±0.06) compared with that of sham-operated rats (0.76 ±0.12), as well as in endotoxemic rats (0.38 ±0.4) compared with control rats (0.82 ±0.11). These data suggest that RBC deformability decreases in both human and murine sepsis. This effect could be an important factor in the disordered oxygen utilization noted in human sepsis, and its correction could lead to better tissue oxygenation and preserved organ function.",

author = "Hurd, {Thelma C.} and Dasmahapatra, {Kumar S.} and Rush, {Benjamin F.} and Machiedo, {George W.}",

year = "1988",

month = feb,

doi = "10.1001/archsurg.1988.01400260101012",

language = "English (US)",

volume = "123",

pages = "217--220",

journal = "JAMA Surgery",

issn = "2168-6254",

publisher = "American Medical Association",

number = "2",

}

TY - JOUR

T1 - Red Blood Cell Deformability in Human and Experimental Sepsis

AU - Hurd, Thelma C.

AU - Dasmahapatra, Kumar S.

AU - Rush, Benjamin F.

AU - Machiedo, George W.

PY - 1988/2

Y1 - 1988/2

N2 - Red blood cell (RBC) “deformability” is necessary for maintenance of normal microcirculation. To determine whether RBC deformability was affected in human or murine sepsis, a deformability index was determined in a human study and a murine model. Deformability was decreased postoperatively in patients with sepsis (0.49 ±0.12) compared with patients without sepsis (1.62±0.13) and normal control volunteers (1.51 ±0.17). Deformability was decreased in rats that had undergone cecal ligation and puncture (0.37±0.06) compared with that of sham-operated rats (0.76 ±0.12), as well as in endotoxemic rats (0.38 ±0.4) compared with control rats (0.82 ±0.11). These data suggest that RBC deformability decreases in both human and murine sepsis. This effect could be an important factor in the disordered oxygen utilization noted in human sepsis, and its correction could lead to better tissue oxygenation and preserved organ function.

AB - Red blood cell (RBC) “deformability” is necessary for maintenance of normal microcirculation. To determine whether RBC deformability was affected in human or murine sepsis, a deformability index was determined in a human study and a murine model. Deformability was decreased postoperatively in patients with sepsis (0.49 ±0.12) compared with patients without sepsis (1.62±0.13) and normal control volunteers (1.51 ±0.17). Deformability was decreased in rats that had undergone cecal ligation and puncture (0.37±0.06) compared with that of sham-operated rats (0.76 ±0.12), as well as in endotoxemic rats (0.38 ±0.4) compared with control rats (0.82 ±0.11). These data suggest that RBC deformability decreases in both human and murine sepsis. This effect could be an important factor in the disordered oxygen utilization noted in human sepsis, and its correction could lead to better tissue oxygenation and preserved organ function.

UR - http://www.scopus.com/inward/record.url?scp=0023840618&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023840618&partnerID=8YFLogxK

U2 - 10.1001/archsurg.1988.01400260101012

DO - 10.1001/archsurg.1988.01400260101012

M3 - Article

C2 - 3277585

AN - SCOPUS:0023840618

SN - 2168-6254

VL - 123

SP - 217

EP - 220

JO - JAMA Surgery

JF - JAMA Surgery

IS - 2

ER -

Red Blood Cell Deformability in Human and Experimental Sepsis

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this