Recurrent stroke and thrombo-occlusive events in the antiphospholipid syndrome

Steven R. Levine, Robin L Brey, Kara L. Sawaya, Leeza Salowich-Palm, James Kokkinos, Beata Kostrzema, Mary Perry, Suzanne Havstad, John Carey

Research output: Contribution to journalArticle

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Abstract

We prospectively studied 81 consecutively identified patients with antiphospholipid antibodies (aPLs) who developed focal cerebral ischemia over a 7-year period. The mean age of this cohort was approximately a decade younger than the average atherothromboembolic stroke victim and women were more commonly involved than men. The frequency of conventional stroke risk factors was lowest in the group of stroke patients with the highest levels of IgG cardiolipin immunoreactivity. Other serological abnormalities associated with aPL (false-positive Veneral Disease Research Laboratory test, thrombocytopenia, prolonged activated partial thromboplastin time [aPTT]) were more common in the group with over 100 GPL units (high positive). Patients with the highest IgG anticardiolipin titers had the shortest times to subsequent thrombo-occlusive events. The most common recurrent event was cerebral infarction, often occurring within the first year of follow-up during a mean prospective follow-up of 3 years. Over one-half of the cohort had at least one recurrent thrombo-occlusive event during follow-up. This distinct syndrome of cerebral ischemia should be recognized for its younger age at onset, predominance of women, high risk of recurrent thrombo-occlusive events, and the possible use of the IgG anticardiolipin antibody titer for prognosis.

Original languageEnglish (US)
Pages (from-to)119-124
Number of pages6
JournalAnnals of Neurology
Volume38
Issue number1
DOIs
StatePublished - Jul 1995

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Antiphospholipid Syndrome
Immunoglobulin G
Stroke
Brain Ischemia
Anticardiolipin Antibodies
Antiphospholipid Antibodies
Cardiolipins
Partial Thromboplastin Time
Cerebral Infarction
Age of Onset
Thrombocytopenia
Research

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Levine, S. R., Brey, R. L., Sawaya, K. L., Salowich-Palm, L., Kokkinos, J., Kostrzema, B., ... Carey, J. (1995). Recurrent stroke and thrombo-occlusive events in the antiphospholipid syndrome. Annals of Neurology, 38(1), 119-124. https://doi.org/10.1002/ana.410380119

Recurrent stroke and thrombo-occlusive events in the antiphospholipid syndrome. / Levine, Steven R.; Brey, Robin L; Sawaya, Kara L.; Salowich-Palm, Leeza; Kokkinos, James; Kostrzema, Beata; Perry, Mary; Havstad, Suzanne; Carey, John.

In: Annals of Neurology, Vol. 38, No. 1, 07.1995, p. 119-124.

Research output: Contribution to journalArticle

Levine, SR, Brey, RL, Sawaya, KL, Salowich-Palm, L, Kokkinos, J, Kostrzema, B, Perry, M, Havstad, S & Carey, J 1995, 'Recurrent stroke and thrombo-occlusive events in the antiphospholipid syndrome', Annals of Neurology, vol. 38, no. 1, pp. 119-124. https://doi.org/10.1002/ana.410380119
Levine SR, Brey RL, Sawaya KL, Salowich-Palm L, Kokkinos J, Kostrzema B et al. Recurrent stroke and thrombo-occlusive events in the antiphospholipid syndrome. Annals of Neurology. 1995 Jul;38(1):119-124. https://doi.org/10.1002/ana.410380119
Levine, Steven R. ; Brey, Robin L ; Sawaya, Kara L. ; Salowich-Palm, Leeza ; Kokkinos, James ; Kostrzema, Beata ; Perry, Mary ; Havstad, Suzanne ; Carey, John. / Recurrent stroke and thrombo-occlusive events in the antiphospholipid syndrome. In: Annals of Neurology. 1995 ; Vol. 38, No. 1. pp. 119-124.
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