Recurrent abruptio placentae in a cynomolgus monkey (Macaca fascicularis)

N. Schlabritz-Loutsevitch, G. Hubbard, J. Zhang, S. Gupta, E. Dick

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Introduction: Abruptio placentae, defined as premature separation of a normally implanted placenta, is a life threatening pregnancy complication with unknown pathophysiology. A history of abruptio placentae is the major risk factor for this pregnancy complication in humans. We describe the first case of recurrent abruptio placentae in a Macaca fascicularis. Material and methods: A pregnant M. fascicularis at term gestation was presented with weakness and hypothermia. Cesarean section revealed retroplacental hemorrhage with partial placental separation from the uterus. Results: The weight of the female fetus was within the lower birth weight range for these species. The maternal side of placenta contained necrotic tissue, occupying approximately 60% of the maternal surface. The placental implantation bed demonstrated neutrophil infiltration. Perivascular collections of lymphocytes were noticed in the uterine smooth muscle. Conclusion: This case report underlines the importance of neutrophil infiltration and uterine venous drainage in the cascade of events leading to abruptio placentae.

Original languageEnglish (US)
Pages (from-to)388-390
Number of pages3
Issue number4
StatePublished - Apr 2013


  • Abruptio
  • Macaques
  • Non-human primates
  • Placenta

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Developmental Biology


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