Recoverin and rhodopsin kinase

Ching Kang Jason Chen

doi:10.1007/978-1-4615-0121-3_6

Recoverin and rhodopsin kinase

Ching Kang Jason Chen

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

The majority of proteins involved in vertebrate phototransduction are expressed specifically in photoreceptors. Recoverin and rhodopsin kinase are expressed primarily in retinal photoreceptors and they interact with each other in a Ca²⁺-dependent manner. This Ca²⁺-dependent interaction has been studied extensively in vitro. Experiments utilizing animal models and electrophysiological approaches have started to provide important insight regarding its in vivo function. Recoverin can be viewed as a negative regulator of rhodopsin kinase in vertebrate phototransduction. This interaction imparts a negative feedback loop at the receptor level and may play an important role in light adaptation and in recovery.

Original language	English (US)
Pages (from-to)	101-107
Number of pages	7
Journal	Advances in experimental medicine and biology
Volume	514
DOIs	https://doi.org/10.1007/978-1-4615-0121-3_6
State	Published - 2002
Externally published	Yes

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1007/978-1-4615-0121-3_6

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abstract = "The majority of proteins involved in vertebrate phototransduction are expressed specifically in photoreceptors. Recoverin and rhodopsin kinase are expressed primarily in retinal photoreceptors and they interact with each other in a Ca2+-dependent manner. This Ca2+-dependent interaction has been studied extensively in vitro. Experiments utilizing animal models and electrophysiological approaches have started to provide important insight regarding its in vivo function. Recoverin can be viewed as a negative regulator of rhodopsin kinase in vertebrate phototransduction. This interaction imparts a negative feedback loop at the receptor level and may play an important role in light adaptation and in recovery.",

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AB - The majority of proteins involved in vertebrate phototransduction are expressed specifically in photoreceptors. Recoverin and rhodopsin kinase are expressed primarily in retinal photoreceptors and they interact with each other in a Ca2+-dependent manner. This Ca2+-dependent interaction has been studied extensively in vitro. Experiments utilizing animal models and electrophysiological approaches have started to provide important insight regarding its in vivo function. Recoverin can be viewed as a negative regulator of rhodopsin kinase in vertebrate phototransduction. This interaction imparts a negative feedback loop at the receptor level and may play an important role in light adaptation and in recovery.

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JO - Advances in experimental medicine and biology

JF - Advances in experimental medicine and biology

ER -

Recoverin and rhodopsin kinase

Abstract

ASJC Scopus subject areas

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