TY - JOUR
T1 - Recombination factors of Saccharomyces cerevisiae
AU - Sung, Patrick
AU - Trujillo, Kelly Miguel
AU - Van Komen, Stephen
N1 - Funding Information:
We are grateful to Jim Haber, John Petrini, and Lorraine Symington for communicating results, and would like to thank Sabrina Stratton for artwork preparation. The studies in the laboratory of the authors have been supported by grants from the NIH (ES07061 and GM57814) and the US Army Medical Research and Material Command (DAMD17-94-J-4147).
PY - 2000/6/30
Y1 - 2000/6/30
N2 - The budding yeast Saccharomyces cerevisiae has been an excellent genetic and biochemical model for our understanding of homologous recombination. Central to the process of homologous recombination are the products of the RAD52 epistasis group of genes, whose functions we now know include the nucleolytic processing of DNA double-stand breaks, the ability to conduct a DNA homology search, and the capacity to promote the exchange of genetic information between homologous regions on recombining chromosomes. It is also clear that the basic functions of the RAD52 group of genes have been highly conserved among eukaryotes. Disruption of this important process causes genomic instability, which can result in a number of unsavory consequences, including tumorigenesis and cell death. Copyright (C) 2000 Elsevier Science B.V.
AB - The budding yeast Saccharomyces cerevisiae has been an excellent genetic and biochemical model for our understanding of homologous recombination. Central to the process of homologous recombination are the products of the RAD52 epistasis group of genes, whose functions we now know include the nucleolytic processing of DNA double-stand breaks, the ability to conduct a DNA homology search, and the capacity to promote the exchange of genetic information between homologous regions on recombining chromosomes. It is also clear that the basic functions of the RAD52 group of genes have been highly conserved among eukaryotes. Disruption of this important process causes genomic instability, which can result in a number of unsavory consequences, including tumorigenesis and cell death. Copyright (C) 2000 Elsevier Science B.V.
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U2 - 10.1016/S0027-5107(00)00054-3
DO - 10.1016/S0027-5107(00)00054-3
M3 - Review article
C2 - 10915877
AN - SCOPUS:0034733599
SN - 0027-5107
VL - 451
SP - 257
EP - 275
JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
IS - 1-2
ER -